# US 8,785,401 B2 · Methods for treating diseases having an inflammatory component related to phospholipase A2

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- Number: US 8,785,401 B2
- Document ID: US8785401B2
- Status: Granted
- Kind: B2
- Application number: 11/988,253
- Filed: 2006-07-10
- Published: 2009-07-16
- Granted: 2014-07-22
- Earliest claimed: 2005-07-08
- Assignees: Philadelphia Health and Education Corporation
- Applicants: Timothy J. Cunningham; Lihua Yao
- Inventors: Timothy J. Cunningham; Lihua Yao
- Web page: https://patentgrep.com/patent/US8785401B2

## CPC

- G01N 33/573: for enzymes or isoenzymes
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- G01N 33/564: for pre-existing immune complex or autoimmune disease {, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9}
- G01N 2333/918: Carboxylic ester hydrolases (3.1.1)
- G01N 2333/92: Triglyceride splitting, e.g. by means of lipase
- G01N 2800/285: Demyelinating diseases; Multipel sclerosis
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.

## Claims

### Claim 1

A method of treating a mammal afflicted with an inflammatory condition, said method comprising administering a therapeutically effective amount of a polypeptide consisting of nine (9) amino acids consisting of the sequence of CHEASAAQC (SEQ ID NO:1) to said mammal, wherein said polypeptide inhibits the activity of phospholipase A2 (PLA2).

### Claim 2 (depends on 1)

The method of claim 1, wherein said polypeptide is administered by at least one route selected from the group consisting of parenterally, orally, intramuscularly, and systemically.