# US 8,785,381 B2 · Oral GLP-1 formulations

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- Number: US 8,785,381 B2
- Document ID: US8785381B2
- Status: Granted
- Kind: B2
- Application number: 12/497,373
- Filed: 2009-07-02
- Published: 2010-01-21
- Granted: 2014-07-22
- Earliest claimed: 2003-12-19
- Assignees: Emisphere Technologies, Inc.
- Applicants: Donald J. Sarubbi
- Inventors: Donald J. Sarubbi
- Web page: https://patentgrep.com/patent/US8785381B2

## CPC

- A61K 38/26: Glucagons
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides pharmaceutical compositions comprising of at least one delivery agent and GLP-1. These pharmaceutical compositions facilitate the oral delivery of GLP-1, providing improved (e.g. increased) bioavailability of GLP-1 compared to administration of GLP-1 without a delivery agent.

## Claims

### Claim 1

A formulation comprising (i) a glucagon-like 1 peptide (GLP-1) compound having the amino acid sequence of SEQ ID NO: 2 and (ii) a delivery agent selected from the group consisting of
and pharmaceutically acceptable salts thereof.

### Claim 2 (depends on 1)

The formulation of claim 1, further comprising an excipient selected from pharmaceutically acceptable buffers, suspending agents, co-solvents, preservatives, isotonicity agents, and combinations thereof.

### Claim 3 (depends on 1)

The formulation of claim 1, in the form of a tablet, capsule or particle.

### Claim 4 (depends on 1)

The formulation of claim 1, wherein the GLP-1 compound is a GLP-1 analog.

### Claim 5 (depends on 1)

The formulation of claim 1, wherein the GLP-1 compound is a GLP-1 derivative.

### Claim 6 (depends on 1)

The formulation of claim 1, wherein the GLP-1 compound is a GLP-1 fragment.