# US 8,785,380 B2 · Formulation containing curcuminoids exhibiting enhanced bioavailability

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- Number: US 8,785,380 B2
- Document ID: US8785380B2
- Status: Granted
- Kind: B2
- Application number: 13/360,005
- Filed: 2012-01-27
- Published: 2013-01-31
- Granted: 2014-07-22
- Earliest claimed: 2011-02-01
- Assignees: M/S Akay Flavours & Aromatics Pvt Ltd
- Applicants: Krishnakumar Illathu Madhavamenon; Abhilas Ravi; Dinesh Kumar; Balu Paulose Maliakel
- Inventors: Krishnakumar Illathu Madhavamenon; Abhilas Ravi; Dinesh Kumar; Balu Paulose Maliakel
- Web page: https://patentgrep.com/patent/US8785380B2

## CPC

- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 31/121: acyclic
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61K 2236/30: Extraction of the material
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a formulation containing curcuminoids exhibiting enhanced in vivo bioavailability and resultant improved efficacy, said formulation comprising curcuminoids and a gel forming, non digestive and soluble dietary polysaccharide fiber galactomannan matrix and proteins derived from fenugreek [Trigonella Foenum graecum]. The invention also relates to a process for producing the formulation and extracting non-digestible soluble dietary polysaccharide fiber galactomannans containing proteins from fenugreek seeds.

## Claims

### Claim 1

A stable formulation comprising curcuminoids impregnated in non-digestive and soluble dietary polysaccharide fiber galactomannan matrix containing fiber content of 80-95% (w/w) and protein content of 5-15% (w/w) derived from fenugreek [Trigonella Foenum graecum] resulting into uniform curcumagalactomannoside particles wherein said formulation exhibits an enhanced in vivo bioavailability of at least 15 times more than curcumin alone.

### Claim 2 (depends on 1)

The formulation of claim 1, wherein said curcumagalactomannoside particles are amorphous in nature.

### Claim 3 (depends on 1)

The formulation of claim 1, wherein curcuminoids are derived from less than 60 weight percentage of dry curcumin powder suspended in excess water containing with or without hydrocolloids under ultrasound mediated ultrasonication, homogenisation or cryogenic grinding.

### Claim 4 (depends on 3)

The formulation of claim 3, wherein curcuminoids are derived preferably from 20-60 weight percentage of dry curcumin powder.

### Claim 5 (depends on 1)

The formulation of claim 1 wherein said polysaccharide fiber galactomannan matrix is obtained by subjecting water soaked and ground fenugreek seeds to alcoholic extraction to remove unwanted flavour and taste, discarding the alcoholic extract and subjecting said treated fenugreek seed mass to water extraction followed by addition of 2 to 5 times alcohol (v/v) to said aqueous extract to precipitate fiber and proteins, said precipitation process being repeated to produce substantially pure fiber and proteins, said fiber optionally being converted into free flowing gelly by employing ultrasonication.

### Claim 6 (depends on 1)

A process for producing a stable formulation as claimed in claim 1, said process comprising the step of grinding a non-digestive soluble dietary polysaccharide fiber galactomannans and proteins derived from fenugreek (Trigonella Foenum graecum) in water under ultrasonication, 20 to 60% w/w of curcuminoids in said fiber resulting in uniform amorphous water soluble curcumagalactomannoside particles.

### Claim 7 (depends on 6)

The process of claim 6, wherein the step of ultrasonication is carried out at 50° C. for different time intervals as pulses of duration from 1 to 3 minutes to form a uniform viscous solution of curcuminoids dispersed in said fiber gel.

### Claim 8 (depends on 7)

The process of claim 7, wherein further comprising the step of evaporating the curcuminoids solution obtained after ultrasonication with said fiber under vacuum at 60-80° C. and granulated.

### Claim 9 (depends on 1)

The formulation of claim 1, wherein the curcumagalactomannoside particles are of about 150±20 micrometers in size.

### Claim 10 (depends on 1)

The formulation of claim 1, formulated for absorption in the intestine.

### Claim 11 (depends on 1)

The formulation of claim 1, wherein the formulation provides stable curcuminoids at a temperature range of 90 to 120° C. and at a pH in the range of 2 to 7.5 in an aqueous solution.

### Claim 12 (depends on 1)

The formulation of claim 1, wherein said formulation is a food grade formulation.