Back to results
US 8,785,374 B2Granted
Inhibitors of mammalian tight junction opening
AssigneeAlba Therapeutics Corporation
InventorAmir Tamiz
Life of this patent
Estimating the term…
Abstract
The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.
Claims14
A method of treating an excessive or undesirable permeability of a tissue containing tight junctions in a subject comprising:
- administering to the subject a pharmaceutical composition comprising a peptide tight junction antagonist having three to five amino acids, and wherein the peptide is defined by the formula:
- X1-X2-X3-X4-X5;
- wherein:
- X1 is optional, and where present is a natural or non-natural amino acid,
- X2 is optional, and where present is a natural or non-natural amino acid,
- X3 is a natural or non-natural amino acid,
- X4 is selected from Pro and Ala, and
- X5 is Gly, Gln, or Ala.
5 more elements
Dependencies are inferred from the claim text.