# US 8,785,188 B2 · Method to formulate T-cells

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- Number: US 8,785,188 B2
- Document ID: US8785188B2
- Status: Granted
- Kind: B2
- Application number: 12/887,039
- Filed: 2010-09-21
- Published: 2011-02-03
- Granted: 2014-07-22
- Earliest claimed: 2003-05-13
- Assignees: Immunovative Therapies Ltd.
- Applicants: Michael Har-Noy
- Inventors: Michael Har-Noy
- Web page: https://patentgrep.com/patent/US8785188B2

## CPC

- A61K 39/0005: {Vertebrate antigens (from snakes A61K39/38)}
- A61K 40/11: T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A61K 40/15: Natural-killer [NK] cells; Natural-killer T [NKT] cells
- A61K 40/30: characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K 40/42: Cancer antigens
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/12: Antivirals
- A61P 33/00: Antiparasitic agents
- A61P 35/00: Antineoplastic agents
- A61P 37/02: Immunomodulators
- A61P 37/04: Immunostimulants
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- C12N 5/0636: {T lymphocytes}
- A61K 40/50: characterised by the use of allogeneic cells
- A61K 2039/57: {characterised by the type of response, e.g. Th1, Th2}
- C12N 2501/51: B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
- C12N 2501/515: CD3, T-cell receptor complex
- C12N 2531/00: Microcarriers
- C12N 2533/40: Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

A method for formulating T-cells for use as a medicant comprises activating the T-cells by incubating the T-cells in a nutrient culture media with an activating agent. The T-cells together with the activating agent are suspended in a media suitable for infusion. The activated T-cells are packaged together with the activating agent in a container suitable for administration to a patient.

## Claims

### Claim 1

A method to formulate T-cells for use as a medicant comprising:
activating the T-cells by incubating the T-cells in a nutrient culture media with an activating agent;
suspending the activated T-cells together with the activating agent in a media suitable for infusion; and
packaging the activated T-cells together with the activating agent in a container suitable for administration to a patient.

### Claim 2 (depends on 1)

The method of claim 1 wherein the T-cells are Th1 cells.

### Claim 3 (depends on 1)

The method of claim 1 wherein the media suitable for infusion is PlasmaLyteA supplemented with human serum albumin.

### Claim 4 (depends on 1)

The method of claim 1 wherein the container is a syringe.