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US 8,785,166 B2Granted
Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
AssigneeButamax Advanced Biofuels LLC
InventorLarry Cameron Anthony
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Abstract
Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.
Claims10
A method for the production of isobutanol comprising growing a recombinant yeast host cell which produces isobutanol and comprises mitochondria which is substantially devoid of threonine deaminase activity, wherein the recombinant yeast cell is grown under conditions wherein isobutanol is produced.
Dependencies are inferred from the claim text.