# US 8,785,141 B2 · Bacterial toxin adsorbing material, method of removing the toxin by adsorbing, and an adsorber formed by filling the adsorbing material therein

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- Number: US 8,785,141 B2
- Document ID: US8785141B2
- Status: Granted
- Kind: B2
- Application number: 10/362,534
- Filed: 2001-08-24
- Published: 2008-09-04
- Granted: 2014-07-22
- Earliest claimed: 2000-08-25
- Assignees: Kaneka Corporation
- Applicants: Tamiji Fujimoto; Fumiyasu Hirai; Shigeo Furuyoshi
- Inventors: Tamiji Fujimoto; Fumiyasu Hirai; Shigeo Furuyoshi
- Web page: https://patentgrep.com/patent/US8785141B2

## CPC

- B01J 20/26: Synthetic macromolecular compounds
- A61M 1/3627: {Degassing devices; Buffer reservoirs; Drip chambers; Blood filters}
- A61M 1/3679: {by absorption (A61M1/3675 takes precedence)}
- B01J 20/20: comprising free carbon; comprising carbon obtained by carbonising processes
- B01J 20/261: {obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F)}
- B01J 20/264: {derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers}
- B01J 20/28078: {Pore diameter}
- Y10T 428/13: Hollow or container type article [e.g., tube, vase, etc.]
- Y10T 428/1376: Foam or porous material containing
- Y10T 428/268: Monolayer with structurally defined element
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The invention aims at providing an adsorbent for bacterial toxins, a method for removal of such toxins by adsorption, and an adsorber packed with said adsorbent. Provided are an adsorbent for bacterial toxins, which comprises a water-insoluble porous material having a mode of pore radius of 20 angstroms to 1,000 angstroms, a method for removal of bacterial toxins using said adsorbent, and an adsorber packed with said adsorbent.

## Claims

### Claim 1

The method for removal of exotoxin by adsorption, which comprises the step of contacting an adsorbent with a bacterial toxin-containing fluid, wherein the adsorbent comprises a water-insoluble porous material having a mode of pore radius of 100 angstroms to 600 angstroms, and wherein the water-insoluble porous material comprises a polystyrene-based material,
wherein the exotoxin is selected from the group consisting of Toxic shock syndrome toxin-1, staphylococcal enterotoxin B, staphylococcal enterotoxin Cl, staphylococcal enterotoxin D, and staphylococcal enterotoxin E,
wherein the polystyrene-based material does not have a side chain or ligand.