# US 8,785,137 B2 · Method for renal disease diagnosis using Rab23 as marker

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,785,137 B2
- Document ID: US8785137B2
- Status: Granted
- Kind: B2
- Application number: 12/948,017
- Filed: 2010-11-17
- Published: 2012-05-24
- Granted: 2014-07-22
- Earliest claimed: 2009-02-10
- Assignees: National Defense Medical Center
- Applicants: Ann Chen; Hao-Ai Shui; Shuk-Man Ka
- Inventors: Ann Chen; Hao-Ai Shui; Shuk-Man Ka
- Web page: https://patentgrep.com/patent/US8785137B2

## CPC

- C12Q 1/6883: for diseases caused by alterations of genetic material
- A61P 13/12: of the kidneys
- C12Q 2600/158: Expression markers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment.

## Claims

### Claim 1

A method for diagnosing a renal disorder in a kidney of a subject suspected of having kidney sclerosis, kidney fibrosis, glomerular injury, kidney failure, glomerulosclerosis, focal segmental glomerulosclerosis or glomerulonephritis, comprising providing a kidney tissue sample obtained from the subject, detecting the level of a biomarker in the kidney tissue sample, and determining whether the subject has one of the said disorders based on the level of the biomarker thus detected; wherein the biomarker is Rab23 and an elevated level of the biomarker in the subject suspected of having the renal disorder higher than in a healthy subject indicates that the subject has the said renal disorder.

### Claim 2 (depends on 1)

The method of claim 1, wherein the detecting step is performed by examining the protein level of Rab23.

### Claim 3 (depends on 1)

The method of claim 1, wherein the detecting step is performed by examining the messenger RNA level of Rab23.