# US 8,785,116 B2 · Methods for evaluating the suitability of an organ for transplant

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- Number: US 8,785,116 B2
- Document ID: US8785116B2
- Status: Granted
- Kind: B2
- Application number: 13/572,332
- Filed: 2012-08-10
- Published: 2014-02-13
- Granted: 2014-07-22
- Earliest claimed: 2012-08-10
- Assignees: Paragonix Technologies, Inc.
- Applicants: Lisa Maria Anderson; Jared Alden Judson
- Inventors: Lisa Maria Anderson; Jared Alden Judson
- Web page: https://patentgrep.com/patent/US8785116B2

## CPC

- G16H 10/40: for data related to laboratory analysis, e.g. patient specimen analysis
- A01N 1/122: Preservation or perfusion media
- A01N 1/143: for organ perfusion
- G01N 33/483: Physical analysis of biological material
- G01N 33/487: of liquid biological material
- G06Q 10/08: Logistics, e.g. warehousing, loading or distribution; Inventory or stock management
- G16H 50/30: for calculating health indices; for individual health risk assessment
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- G06Q: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR

## Abstract

Methods of determining the health of an organ, such as a transplant organ, by measuring the ex-situ oxygen consumption rate of the organ. Systems for preserving and transporting organs while monitoring viability by measuring oxygen consumption rates.

## Claims

### Claim 1

A method of evaluating the suitability of an organ for transplant comprising:
perfusing the organ at hypothermic temperatures with an oxygenated solution using a mobile perfusion machine comprising a pneumatic system that oxygenates a preservation solution to create the oxygenated solution while varying the pressure of the oxygenated solution with the pneumatic system at least once per minute to create a differential perfusion pressure between about 5 mm Hg to about 30 mm Hg;
measuring the oxygen consumption rate of the organ; and
comparing the measured oxygen consumption rate to a functional oxygen consumption rate, wherein a measured oxygen consumption rate greater than or equal to a functional oxygen consumption rate is indicative of a suitable organ.

### Claim 2 (depends on 1)

The method of claim 1, wherein the functional oxygen consumption rate is greater than or equal to 50 nmo1O2/min/g of organ mass.

### Claim 3 (depends on 1)

The method of claim 1, wherein the organ is selected from the group consisting of heart, kidney, liver, lung, and pancreas.

### Claim 4 (depends on 1)

The method of claim 1, wherein the organ is perfused at a temperature of less than 10° C.

### Claim 5 (depends on 1)

The method of claim 1, wherein the organ is from an expanded criteria donor (ECD) or from a donation after cardiac death (DCD).

### Claim 6 (depends on 1)

The method of claim 1, additionally comprising monitoring vascular resistance of the organ to perfusion.

### Claim 7 (depends on 1)

The method of claim 1, wherein the mobile perfusion machine varies the pressure on the oxygenated solution at least once every 10 seconds.

### Claim 8 (depends on 1)

The method of claim 1, wherein the mobile perfusion machine additionally comprises one or more oxygen sensors.

### Claim 9 (depends on 1)

The method of claim 1, wherein the mobile perfusion machine oxygenates the preservation solution with a partial pressure of oxygen of at least 100 mmHg (100 Torr).

### Claim 10 (depends on 8)

The method of claim 8, wherein the mobile perfusion machine displays a value indicative of the oxygen consumption rate of the organ.