# US 8,784,905 B2 · Oil-extracted product of indigo naturalis, and preparation process and uses thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,784,905 B2 - Document ID: US8784905B2 - Status: Granted - Kind: B2 - Application number: 13/274,506 - Filed: 2011-10-17 - Published: 2012-08-23 - Granted: 2014-07-22 - Earliest claimed: 2011-02-18 - Assignees: Galderma Research & Development, S.N.C. - Applicants: Yin-Ku Lin - Inventors: Yin-Ku Lin - Web page: https://patentgrep.com/patent/US8784905B2 ## CPC - A61K 36/315: Isatis, e.g. Dyer's woad - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} - A61P 17/00: Drugs for dermatological disorders - A61P 17/06: Antipsoriatics - A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) - A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Disclosed herein are an oil-extracted product of indigo naturalis, and the preparation process thereof. Also disclosed are a pharmaceutical composition containing the oil-extracted product of indigo naturalis and a method for treating a human subject having or suspected to have a psoriatic disease such as skin psoriasis and nail psoriasis. ## Claims ### Claim 1 An oil-extracted product of indigo naturalis which is obtained by a process comprising extracting indigo naturalis powder with an oil under heating, followed by a refining treatment by filtration, wherein in said process, extracting indigo naturalis powder is conducted at a temperature ranging from 100° C. to 155° C. ### Claim 2 (depends on 1) The oil-extracted product of indigo naturalis as claimed in claim 1, which comprises indirubin. ### Claim 3 (depends on 1) The oil-extracted product of indigo naturalis as claimed in claim 1, wherein in said process, the oil-extracted product obtained after the refining treatment has a decreased indigo content. ### Claim 4 (depends on 1) The oil-extracted product from indigo naturalis as claimed in claim 1, wherein the oil used in said process is selected from the group consisting of vegetable oils, animal oils, mineral oils, and combinations thereof. ### Claim 5 (depends on 4) The oil-extracted product from indigo naturalis as claimed in claim 4, wherein the oil is a vegetable oil selected from the group consisting of olive oil, cottonseed oil, sesame oil, sunflower seed oil, peanut oil, wheat germ oil, soybean oil, jojoba oil, evening primrose oil, coconut oil, palm oil, sweet almond oil, aloe oil, apricot kernel oil, avocado oil, borage oil, hemp seed oil, macadamia nut oil, rose hip oil, pecan oil, hazelnut oil, sasanqua oil, rice bran oil, shea butter, corn oil, camellia oil, grape seed oil, canola oil, castor oil, and combinations thereof. ### Claim 6 (depends on 1) A pharmaceutical composition comprising an oil-extracted product of indigo naturalis as claimed in claim 1. ### Claim 7 (depends on 6) A method for treating a human subject having or suspected to have a psoriatic disease, comprising treating said human subject with a pharmaceutical composition as claimed in claim 6. ### Claim 8 (depends on 7) The method of claim 7, wherein the psoriatic disease is selected from skin psoriasis, nail psoriasis, chronic plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, pustular psoriasis, and combinations thereof. ### Claim 9 (depends on 7) The method of claim 7, wherein an additional anti-psoriatic drug is used to treat said subject. ### Claim 10 (depends on 6) The pharmaceutical composition of claim 6, wherein in said process, the oil-extracted product obtained after the refining treatment has a decreased indigo content. ### Claim 11 (depends on 7) The method of claim 7, wherein in said process, the oil-extracted product obtained after the refining treatment has a decreased indigo content. ### Claim 12 A process for preparing an oil-extracted product of indigo naturalis, comprising subjecting indigo naturalis powder to an extraction treatment using an oil under heating and subsequent to the extraction treatment, performing a refining treatment by filtration, wherein the extraction treatment is conducted at a temperature ranging from 100° C. to 155° C. ### Claim 13 (depends on 12) The process of claim 12, wherein the oil used in the extraction treatment is selected from the group consisting of vegetable oils, animal oils, mineral oils, and combinations thereof. ### Claim 14 (depends on 13) The process of claim 13, wherein the oil used in the extraction treatment is a vegetable oil selected from the group consisting of olive oil, cottonseed oil, sesame oil, sunflower seed oil, peanut oil, wheat germ oil, soybean oil, jojoba oil, evening primrose oil, coconut oil, palm oil, sweet almond oil, aloe oil, apricot kernel oil, avocado oil, borage oil, hemp seed oil, macadamia nut oil, rose hip oil, pecan oil, hazelnut oil, sasanqua oil, rice bran oil, shea butter, corn oil, camellia oil, grape seed oil, canola oil, castor oil, and combinations thereof.