# US 8,784,901 B2 · Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide

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- Number: US 8,784,901 B2
- Document ID: US8784901B2
- Status: Granted
- Kind: B2
- Application number: 14/145,126
- Filed: 2013-12-31
- Published: 2014-05-08
- Granted: 2014-07-22
- Earliest claimed: 1999-10-04
- Assignees: S.K. Pharmaceuticals, Inc.
- Applicants: S.K. Pharmaceuticals, Inc.
- Inventors: Hampar L. Karagoezian
- Web page: https://patentgrep.com/patent/US8784901B2

## CPC

- A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61K 31/728: Hyaluronic acid
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/14: Alkali metal chlorides; Alkaline earth metal chlorides
- A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine
- A61K 33/22: Boron compounds
- A61K 33/40: Peroxides
- A61L 12/10: Halogens or compounds thereof
- A61L 12/124: {Hydrogen peroxide; Peroxy compounds}
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/06: Antipsoriatics
- A61P 27/02: Ophthalmic agents
- A61P 27/04: Artificial tears; Irrigation solutions
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 31/12: Antivirals
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

## Claims

### Claim 1

An anti-microbial preservative for use in an ophthalmic product, the preservative consisting of from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt % peroxy compound, wherein the preservative does not contain chlorine dioxide prior to application to the eye of an individual, and wherein the preservative is at a pH range between about 6.0 and about 8.8.

### Claim 2 (depends on 1)

The preservative of claim 1 wherein the chlorite compound is a metal chlorite.

### Claim 3 (depends on 2)

The preservative of claim 2 wherein the metal is sodium.

### Claim 4 (depends on 2)

The preservative of claim 2 wherein the metal is selected from the group consisting of potassium, calcium, and magnesium.

### Claim 5 (depends on 1)

The preservative of claim 1 wherein the peroxy compound is hydrogen peroxide.

### Claim 6 (depends on 1)

The preservative of claim 1 wherein the ophthalmic product is an artificial tear solution.

### Claim 7 (depends on 1)

The preservative of claim 1 wherein the ophthalmic product is a contact lens disinfecting solution.

### Claim 8 (depends on 1)

The preservative of claim 1 wherein the ophthalmic product is a contact lens cleaning solution.

### Claim 9 (depends on 8)

The preservative of claim 8 wherein the cleaning solution is directly applied to a contact lens in place on an eye of a living being.