# US 8,784,894 B2 · Methods and devices for forming treatment agent carriers

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- Number: US 8,784,894 B2
- Document ID: US8784894B2
- Status: Granted
- Kind: B2
- Application number: 11/485,934
- Filed: 2006-07-12
- Published: 2008-01-17
- Granted: 2014-07-22
- Earliest claimed: 2006-07-12
- Assignees: Abbott Cardiovascular Systems Inc.
- Applicants: Shubhayu Basu; Eugene T. Michal
- Inventors: Shubhayu Basu; Eugene T. Michal
- Web page: https://patentgrep.com/patent/US8784894B2

## CPC

- A61K 9/4833: {Encapsulating processes; Filling of capsules (mechanical aspects A61J3/07)}
- A61K 9/145: {with organic compounds}
- A61K 9/5031: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)}
- A61K 38/30: Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 {(insulin-like growth factor binding protein A61K38/1754)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

## Claims

### Claim 1

A method comprising:
passing a solution comprising a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form charged particles encapsulating the treatment agent;
exposing the charged particles emitted from the electrocharged nozzle to a grounded electrode having a charge opposite that of the nozzle, wherein the grounded electrode is positioned a distance from the electrocharged nozzle sufficient to draw the charged particles toward a collection assembly and allow for solidification of the charged particles through solvent evaporation from the charged particles while the charged particles are traveling to the collection assembly; and
depositing the charged particles in the collection assembly, wherein the collection assembly comprises a liquid phase, the liquid phase comprising a polar solvent and the grounded electrode is positioned within the liquid phase,
wherein the biodegradable polymer is insoluble in the liquid phase.

### Claim 2 (depends on 1)

The method of claim 1, wherein the grounded electrode is positioned between the nozzle and the collection assembly.

### Claim 3 (depends on 1)

The method of claim 1, wherein the collection assembly comprises a collection vessel having the liquid phase disposed therein.

### Claim 4 (depends on 1)

The method of claim 1, wherein the charged particles are one of a microsphere or a nanosphere.

### Claim 5 (depends on 1)

The method of claim 1, wherein the treatment agent is selected from the group consisting of angiogenesis promoting factors, cell survival promoting factors and endogenous recruiting factors.

### Claim 6 (depends on 1)

The method of claim 1, wherein the grounded electrode is one of a ring, a cylinder or a disc.

### Claim 7 (depends on 1)

The method of claim 1, wherein the liquid phase comprises a liquid in which the polymer is insoluble.

### Claim 8 (depends on 1)

The method of claim 1, further comprising separating charged particles suspended in the liquid phase of the collection assembly by at least one of sedimentation, centrifugation, filtration or freeze drying.

### Claim 9 (depends on 1)

The method of claim 1, wherein the solution further comprises an excipient.

### Claim 10 (depends on 1)

The method of claim 1 further comprising:
controlling a size of the charged particles by modifying a voltage applied to the electrocharged nozzle.

### Claim 11 (depends on 1)

The method of claim 1 further comprising:
controlling a size of the charged particles by modifying the distance between the electrocharged nozzle and the grounded electrode.