# US 8,784,892 B2 · Method and composition for burned skin > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,784,892 B2 - Document ID: US8784892B2 - Status: Granted - Kind: B2 - Application number: 12/831,349 - Filed: 2010-07-07 - Published: 2011-05-12 - Granted: 2014-07-22 - Earliest claimed: 2004-03-04 - Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem - Applicants: Elka Touitou - Inventors: Elka Touitou - Web page: https://patentgrep.com/patent/US8784892B2 ## CPC - A61K 31/78: of acrylic acid or derivatives thereof - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates - A61K 47/02: Inorganic compounds - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention is directed to the use of an agent selected from ethyl alcohol, isopropyl alcohol or a mixture thereof and a topically acceptable polymeric carrier in the preparation of a composition for the treatment of burns. ## Claims ### Claim 1 A method for treating a burn, the method comprising applying to the burned area a composition in the form of a gel, comprising ethyl alcohol and a topically acceptable polymeric carrier which forms a gel-like matrix with said ethyl alcohol, wherein the concentration of ethyl alcohol is in the range of 20-50% based on the total weight of the composition, and the treatment impedes micro-vascular destruction and progression associated with the burn. ### Claim 2 (depends on 1) The method according to claim 1, wherein the polymeric carrier comprises an acidic polymer or a salt thereof. ### Claim 3 (depends on 2) The method according to claim 2, wherein the acidic polymer is an acrylic polymer. ### Claim 4 (depends on 3) The method according to claim 3, wherein the acrylic polymer is a carbomer. ### Claim 5 (depends on 3) The method according to claim 3, wherein the acrylic polymer is at least partially neutralized with a base. ### Claim 6 (depends on 5) The method according to claim 5, wherein the base is a nitrogen containing base. ### Claim 7 (depends on 6) The method according to claim 6, wherein the base is selected from the group consisting of ammonium hydroxide, dialkanolamines and trialkanolamines. ### Claim 8 (depends on 7) The method according to claim 7, wherein the concentration of ethanol is from 20% to 50%, the concentration of acrylic polymer is from 0.05% to 5% and the base is ammonium hydroxide at a concentration of from 0.1% to 10%. ### Claim 9 (depends on 7) The method according to claim 7, wherein the concentration of ethanol is from 20% to 50% w/w, the concentration of acrylic polymer is from 0.05% to 5% and the base is triethanolamine at a concentration of 0.1% to 6%. ### Claim 10 (depends on 1) The method according to claim 1, wherein the composition further comprises urea. ### Claim 11 (depends on 1) The method according to claim 1, wherein the composition further comprises plant derived material. ### Claim 12 (depends on 11) The method according to claim 11, wherein the plant derived material is in the form of one or more plant extracts, one or more tinctures, one or more oils and/or one or more macerates. ### Claim 13 (depends on 12) The method according to claim 12, wherein the plant is selected from the group consisting of arnica, plantago, equisetum, lavender, joubarbe, hamamelis, urtica, calendula, daucus, symphytum, sanguisorba, symphytum, aloe vera, roman chamomile, tea tree, witch hazel, Emu, Celosia Argentea and mameluca, and combinations thereof. ### Claim 14 (depends on 1) The method according to claim 1, wherein the composition further comprises one or more ingredients selected from the group consisting of a local anesthetic, antibiotic, plant extract, vitamin, growth factor, protein, histamine, carnosine, insulin, antiinflammatory agent, antiseptic agent, antifungal agent, anticytokine, an interleukin, growth hormone and re-epithelization factors, and combinations thereof. ### Claim 15 (depends on 1) The method according to claim 1, wherein the topically acceptable carrier comprises chitin, guar, chitosan, polyvinylpyrrolidone, polyvinylalcohol, gum, silastic, eudragit, pectin, hyaluronic acid, hyaluronate, gelatin, gelatin derivative, agar, polymer adhesives, polaxomers, methylcelluose, ethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, or a mixture thereof. ### Claim 16 (depends on 1) The method of claim 1, wherein the burn is caused by a scald. ### Claim 17 (depends on 1) The method of claim 1, wherein the burn is a second degree burn. ### Claim 18 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is from 20% to 40%. ### Claim 19 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is about 20%. ### Claim 20 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is about 30%. ### Claim 21 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is about 35%. ### Claim 22 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is about 40%. ### Claim 23 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is about 45%. ### Claim 24 (depends on 1) The method of claim 1, wherein the concentration of ethyl alcohol in the composition is about 50%. ### Claim 25 (depends on 1) The method of claim 1, wherein the composition is applied within about one hour of burn onset. ### Claim 26 (depends on 1) The method of claim 1, with the proviso that the composition is free of local anesthetic.