# US 8,784,883 B2 · Capsule comprising low-substituted cellulose ether and method for preparing the same

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- Number: US 8,784,883 B2
- Document ID: US8784883B2
- Status: Granted
- Kind: B2
- Application number: 13/222,600
- Filed: 2011-08-31
- Published: 2011-12-22
- Granted: 2014-07-22
- Earliest claimed: 2003-12-25
- Assignees: Shin-Etsu Chemical Co., Ltd.
- Applicants: Kazuhisa Hayakawa; Naosuke Maruyama; Miyuki Fukasawa
- Inventors: Kazuhisa Hayakawa; Naosuke Maruyama; Miyuki Fukasawa
- Web page: https://patentgrep.com/patent/US8784883B2

## CPC

- A61K 9/4816: {Wall or shell material}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A capsule with good disintegration properties that can quickly display its content's efficacy as well as a method for preparing the same are provided. More specifically, provided is a capsule comprising a shell comprising low-substituted cellulose ether. Also, provided is a method for preparing a hard capsule comprising the low-substituted cellulose ether comprising a step of covering a pin for forming the hard capsule with the low-substituted cellulose ether by immersing the pin in an alkaline solution of the low-substituted cellulose ether; a step of forming the low-substituted cellulose on a surface of the pin into a gel by further immersing the covered pin in an aqueous acid solution; a step of washing by immersing the pin whose surface has been covered with the gel in water; and a step of drying.

## Claims

### Claim 1

A method for preparing a hard capsule comprising low-substituted cellulose ether, the method comprising:
a step of covering a pin for forming the hard capsule with the low-substituted cellulose ether by immersing the pin in an alkaline solution of the low-substituted cellulose ether;
a step of forming the low-substituted cellulose on a surface of the pin into a gel by further immersing the covered pin in an aqueous acid solution;
a step of washing by immersing in water the pin whose surface has been covered with the gel; and
a step of drying;
wherein the low-substituted cellulose ether is insoluble in water, but swells by absorbing water, and is soluble in an aqueous alkaline solution; and
wherein the low-substituted cellulose ether has a substitution degree of 0.1-0.8.