Controlled release compositions for modulating free-radical induced damage and methods of use thereof
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Abstract
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Claims9
A pharmaceutical composition for treating an otic disease or condition associated with free-radical induced damage, the composition comprising:
- between about 0.1% to about 10% by weight of a micronized free-radical modulating agent, or pharmaceutically acceptable prodrug or salt thereof;
- a polyoxyethylene-polyoxypropylene copolymer in an amount sufficient to provide a gelation temperature between about 19° C. to about 42° C., and a gelation viscosity between about 15,000 cP and about 1,000,000 cP;
- and having
- less than about 50 colony forming units (cfu) of microbiological agents per gram of composition,
- wherein the composition provides sustained release of the free-radical modulating agent into the ear for a period of at least 5 days.
A method of alleviating free-radical induced damage associated with an otic intervention comprising administering to an individual in need thereof an intratympanic composition, the composition comprising
- between about 0.1% to about 10% by weight of a micronized free-radical modulating agent, or pharmaceutically acceptable prodrug or salt thereof;
- a polyoxyethylene-polyoxypropylene copolymer in an amount sufficient to provide a gelation temperature between about 19° C. to about 42° C., and a gelation viscosity between about 15,000 cP and about 1,000,000 cP;
- and having
- less than about 50 colony forming units (cfu) of microbiological agents per gram of composition,
- wherein the composition provides sustained release of the free-radical modulating agent into the ear for a period of at least 5 days.
Dependencies are inferred from the claim text.