# US 8,784,867 B2 · Contact lenses containing carotenoid and method for making same

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- Number: US 8,784,867 B2
- Document ID: US8784867B2
- Status: Granted
- Kind: B2
- Application number: 13/716,496
- Filed: 2012-12-17
- Published: 2013-07-11
- Granted: 2014-07-22
- Earliest claimed: 2011-12-21
- Assignees: Novartis AG
- Applicants: Novartis AG
- Inventors: Newton T. Samuel; Nirupama Kenkare; Peter D. Lackey; Jessie Chen
- Web page: https://patentgrep.com/patent/US8784867B2

## CPC

- A61K 9/0051: {Ocular inserts or implants}
- A61K 31/355: Tocopherols, e.g. vitamin E
- C07C 403/24: having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
- G02B 1/043: {Contact lenses}
- A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts}
- C09B 61/00: Dyes of natural origin prepared from natural sources {, e.g. vegetable sources}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- C09B: ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES {, e.g. PIGMENTS}; MORDANTS; LAKES (fermentation or enzyme using processes to synthesise a desired chemical compound C12P)

## Abstract

The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamin E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.

## Claims

### Claim 1

A method for preparing a contact lens, comprising the steps of:
(a) obtaining a contact lens,
(b) immersing the contact lens in a solution containing a carotenoid and a vitamin E material; for a period of time sufficient to load a desired amount of a carotenoid and a vitamin E material; and
(c) autoclaving the contact lens of step (b) to sterilize the contact lens, wherein the contact lens has a lower oxidative degradation of carotenoids during lens autoclave and/or lens storage by at least about 30% in comparison to an identical contact lens without the vitamin E material.

### Claim 2 (depends on 1)

The method of claim 1 wherein the contact lens comprises a hydrophilic silicon-containing polymer.

### Claim 3 (depends on 1)

The method of claim 1 wherein the vitamin E material is selected from the group consisting of vitamin E, salts of vitamin E, derivatives of vitamin E and mixtures thereof.

### Claim 4 (depends on 1)

The method of claim 1 wherein the carotenoid is selected from the group consisting of Beta-Carotene, lycopene, astaxanthin, Lutein and mixtures thereof.

### Claim 5 (depends on 1)

The method of claim 1 wherein the carotenoid is Beta-Carotene.

### Claim 6 (depends on 1)

The method of claim 1 in step (b) wherein the contact lens are immersed in the solution of vitamin E material and Carotenoid containing about 0.0005 wt % to 0.1 wt % by weight of Carotenoid and 0.05 wt % to 0.5 wt % of vitamin E.

### Claim 7 (depends on 1)

The method of claim 1 wherein the contact lens comprises the vitamin E in an amount of from 50 μg to 250 μg and the Carotenoid in amount of 0.5 μg to 50 μg.

### Claim 8

A contact lens, comprising: a formed water swellable, polymeric lens body; a carotenoids and a vitamin E material, wherein the vitamin E material is present in an amount sufficient to reduce oxidative degradation of the carotenoids during lens autoclave and/or lens storage by at least about 30% in comparison to an identical contact lens without the vitamin E material.

### Claim 9 (depends on 8)

The contact lens of claim 8, wherein polymeric lens body comprises a hydrophilic silicon-containing polymer.

### Claim 10 (depends on 8)

The contact lens of claim 8, wherein the vitamin E material is selected from the group consisting of vitamin E, salts of vitamin E, derivatives of vitamin E and mixtures thereof.

### Claim 11 (depends on 8)

The contact lens of claim 8, wherein the carotenoid is selected from the group consisting of Beta-Carotene, lycopene, astaxanthin, Lutein and mixtures thereof.

### Claim 12 (depends on 9)

The contact lens of claim 9 wherein the carotenoid is Beta-Carotene.

### Claim 13 (depends on 8)

The contact lens of claim 8, wherein the contact lens comprises the vitamin E in an amount of from 50 μg to 250 μg and carotenoid in an amount of from 0.5 μg to 50 μg.

### Claim 14 (depends on 8)

The contact lens of claim 8, wherein the contact lens comprises carotenoid in an amount of from 0.5 μg to 5 μg.