# US 8,784,859 B2 · Biobeneficial coating compositions and methods of making and using thereof

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- Number: US 8,784,859 B2
- Document ID: US8784859B2
- Status: Granted
- Kind: B2
- Application number: 13/905,423
- Filed: 2013-05-30
- Published: 2013-10-03
- Granted: 2014-07-22
- Earliest claimed: 2003-11-26
- Assignees: Abbott Cardiovascular Systems Inc.
- Applicants: Abbott Cardiovascular Systems Inc.
- Inventors: Stephen D. Pacetti
- Web page: https://patentgrep.com/patent/US8784859B2

## CPC

- A61K 9/284: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone}
- A61L 31/10: Macromolecular materials
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61P 35/00: Antineoplastic agents
- A61L 2300/252: Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/41: Anti-inflammatory agents, e.g. NSAIDs
- A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.

## Claims

### Claim 1

A method of treating a disorder in a subject by implanting in the subject an implantable device, wherein the implantable device comprising a coating which comprises a composition, wherein the composition comprises
(1) a first block copolymer having the following structure:
wherein m and n are positive integers, and
(2) a second block copolymer comprising
(i) a biobeneficial component selected from the group consisting of sodium hyaluronate, hyaluronic acid, heparin, and 4-amino-2,2,6,6-tetramethylpiperidine-1-oxide; and
(ii) a component miscible with the first block copolymer selected from the group consisting of polystyrene-polyisobutylene-polystyrene block copolymer (SIS), polystyrene, and polyisobutylene.

### Claim 2 (depends on 1)

The method of claim 1 wherein the second block copolymer is selected from the group consisting of SIS-hyaluronic acid (HA), polystyrene-HA, polyisobutylene-HA SIS-heparin, polystyrene-heparin, and polyisobutylene-heparin.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition further comprises a bioactive agent.

### Claim 4 (depends on 3)

The method of claim 3, wherein the bioactive agent is selected from the group consisting of proteins, peptides, anti-inflammatory agents, antivirals, anticancer drugs, anticoagulant agents, free radical scavengers, and a combination thereof.

### Claim 5 (depends on 3)

The method of claim 3, wherein the bioactive agent is selected from the group consisting of everolimus, sirolimus, sirolimus derivatives, paclitaxel, estradiol, steroidal anti-inflammatory agents, antibiotics, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, ABT-578, clobetasol, cytostatic agents, and a combination thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the implantable device is a stent.

### Claim 7 (depends on 3)

The method of claim 3, wherein the implantable device is a stent.

### Claim 8 (depends on 7)

The method of claim 7, wherein the implantable device is a drug eluting stent (DES).

### Claim 9 (depends on 1)

The method of claim 1, wherein the subject is a human, and wherein disorder is selected from the group consisting of stenosis, occlusions of the arterial vasculature, and vulnerable plaque.

### Claim 10

A method of treating a disorder in a subject by implanting in the subject an implantable device, wherein the implantable device comprising a coating which comprises a composition, wherein the composition comprises
(1) a first block copolymer having the following structure:
wherein m and n are positive integers, and
(2) a second block copolymer selected from the group consisting of SIS-hyaluronic acid (HA), polystyrene-HA, and polyisobutylene-HA.

### Claim 11 (depends on 10)

The method of claim 10, wherein the second block copolymer is polystyrene-HA.