# US 8,784,844 B2 · Arabinogalactan for enhancing the adaptive immune response

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- Number: US 8,784,844 B2
- Document ID: US8784844B2
- Status: Granted
- Kind: B2
- Application number: 12/894,266
- Filed: 2010-09-30
- Published: 2011-03-31
- Granted: 2014-07-22
- Earliest claimed: 2009-09-30
- Assignees: Lonza Ltd.
- Applicants: Bryan Rodriguez; Kevin Q. Owen; Ulla Freitas; Jay Udani
- Inventors: Bryan Rodriguez; Kevin Q. Owen; Ulla Freitas; Jay Udani
- Web page: https://patentgrep.com/patent/US8784844B2

## CPC

- A61K 39/39: characterised by the immunostimulating additives, e.g. chemical adjuvants
- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K 39/092: {Streptococcus}
- A61P 31/04: Antibacterial agents
- C08B 37/0003: {General processes for their isolation or fractionation, e.g. purification or extraction from biomass}
- C08B 37/006: {Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof}
- C08L 5/00: Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- A61K 2039/54: {characterised by the route of administration}
- A61K 2039/55583: {Polysaccharides}
- A61K 2039/70: {Multivalent vaccine}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

The present invention discloses a composition containing Arabinogalactan for enhancing the adaptive immune response in subjects to foreign antigen(s) by administering said composition prior, during and after the phase of exposure to said foreign antigen(s). Furthermore, the present invention relates to a vaccination kit comprising a composition comprising Arabinogalactan and a vaccine.

## Claims

### Claim 1

A kit comprising a composition consisting essentially of: 1) the polysaccharide Arabinogalactan and/or at least one Arabinogalactan derivative, and 2) a vaccine, wherein said Arabinogalactan derivative is selected from the group consisting of Arabinogalactan proteins and quaternized forms of Arabinogalactan.

### Claim 2 (depends on 1)

The kit according to claim 1, whereby said vaccine is a pneumococcal vaccine.

### Claim 3 (depends on 1)

The kit according to claim 1, wherein said Arabinogalactan is derived from plants.

### Claim 4 (depends on 2)

The kit according to claim 2, whereby said pneumococcal vaccine is directed against bacteria from the strain Streptococcus pneumoniae.

### Claim 5

A method for enhancing the adaptive immune response against foreign antigen(s), the method comprising administration of a composition consisting essentially of: 1) the polysaccharide Arabinogalactan and/or at least one Arabinogalactan derivative, and 2) a vaccine, wherein said Arabinogalactan derivative is selected from the group consisting of Arabinogalactan proteins and quaternized forms of Arabinogalactan.