# US 8,784,834 B2 · Recombinant fusion interferon for animals

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- Number: US 8,784,834 B2
- Document ID: US8784834B2
- Status: Granted
- Kind: B2
- Application number: 13/557,139
- Filed: 2012-07-24
- Published: 2014-01-30
- Granted: 2014-07-22
- Earliest claimed: 2012-07-24
- Assignees: SBC Virbac Biotech Co., Ltd.
- Applicants: Tsun-Yung Kuo; Chung-Chin Wu; Han-Ting Chen
- Inventors: Tsun-Yung Kuo; Chung-Chin Wu; Han-Ting Chen
- Web page: https://patentgrep.com/patent/US8784834B2

## CPC

- C07K 14/555: Interferons [IFN]
- A61P 31/12: Antivirals
- C07K 14/56: IFN-alpha
- C07K 19/00: Hybrid peptides {, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes}
- C07K 2319/30: Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a Fc region of an animal immunoglobulin G (IgG). The animal interferon and the Fc region of the animal immunoglobulin G can be further joined by a linker. A polynucleotide that encodes the recombinant fusion interferon for animals, a method for producing the recombinant fusion interferon, and the use of the recombinant fusion interferon.

## Claims

### Claim 1

A recombinant fusion interferon, comprising:
a porcine interferon consisting of the amino acid sequence of SEQ ID NO: 2; and a porcine immunoglobulin Fc fragment consisting of the amino acid sequence of SEQ ID NO: 4, wherein the recombinant fusion interferon has a greater antivirus activity than a non-fusion porcine interferon for inhibition of a porcine virus.

### Claim 2 (depends on 1)

A composition, comprising the recombinant fusion interferon of claim 1 and a pharmaceutically acceptable excipient.

### Claim 3 (depends on 1)

The recombinant fusion interferon of claim 1, wherein the porcine virus is porcine reproductive and respiratory syndrome virus (PRRSV).

### Claim 4 (depends on 1)

The recombinant fusion interferon of claim 1, wherein the porcine virus is pseudorabies virus (PRV).