# US 8,784,803 B2 · Therapeutic agent for liver-related diseases

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- Number: US 8,784,803 B2
- Document ID: US8784803B2
- Status: Granted
- Kind: B2
- Application number: 13/393,023
- Filed: 2010-08-27
- Published: 2012-06-21
- Granted: 2014-07-22
- Earliest claimed: 2009-08-28
- Assignees: Osaka Air Machine Service, Ltd.
- Applicants: Akifumi Matsuyama
- Inventors: Akifumi Matsuyama
- Web page: https://patentgrep.com/patent/US8784803B2

## CPC

- C12N 5/0667: {Adipose-derived stem cells [ADSC]; Adipose stromal stem cells}
- A61K 35/28: Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/06: Antihyperlipidemics
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a therapeutic agent for liver-related diseases, comprising adipose tissue-derived multilineage progenitor cells; and others.

## Claims

### Claim 1

A method for treating a liver-related disease, comprising:
administering adipose tissue-derived multilineage progenitor cells to a subject,
wherein the adipose tissue-derived multilineage progenitor cells are a population of cells obtained by:
(a) removing erythrocytes from a population of adipose tissue-derived cells, thereby to form a population of preadipose tissue-derived multilineage progenitor cells;
(b) culturing the resultant population of the preadipose tissue-derived multilineage progenitor cells;
(c) removing cells other than the adipose tissue-derived multilineage progenitor cells using ethylenediaminetetraacetic acid (EDTA) and without using trypsin.

### Claim 2 (depends on 1)

The method according to claim 1, wherein adipose tissue-derived multilineage progenitor cells are administered via portal vein.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the liver-related disease is non-inflammatory.

### Claim 4 (depends on 3)

The method according to claim 3, wherein the liver-related disease is hemophilia or familial hypercholesterolemia.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the liver-related disease is selected from blood coagulation disorders, metabolic diseases, and liver diseases.