Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
AssigneeCytori Therapeutics, Inc.
InventorsZeni Alfonso, John K. Fraser
Life of this patent
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Abstract
Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate expansion, repair, and/or regeneration of the lymphatic system. The invention further provides using adipose-tissue-derived lymphatic endothelial cells and cells capable of differentiating into lymphatic endothelial cells for delivery of therapeutic agents to tumor cells as a means for treating malignant disease, and assays to screen for drugs that modulate lymphatic system expansion, repair or regeneration.
Claims8
A method of lymphatic endothelial cell (LEC) and pre-LEC transplantation in a mammal comprising:
- identifying a mammal in need of LECs or pre-LECs;
- and
- providing an isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs, wherein greater than 5% of said population of adipose-derived cells express FLT-4, to said identified mammal.
A method of inducing expansion of lymph vessels in a mammal comprising:
- identifying a mammal in need of an expansion of lymph vessels;
- and
- providing an isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs, wherein greater than 5% of said population of adipose-derived cells express FLT-4, to said identified mammal.
Dependencies are inferred from the claim text.