# US 8,784,779 B2 · Color change of chalcone-containing oral care formulations

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- Number: US 8,784,779 B2
- Document ID: US8784779B2
- Status: Granted
- Kind: B2
- Application number: 13/520,751
- Filed: 2011-01-06
- Published: 2013-08-01
- Granted: 2014-07-22
- Earliest claimed: 2010-01-07
- Assignees: Colgate-Palmolive Company
- Applicants: Lyndsay Schaeffer-Korbylo; Gregory Szewczyk; Laurence Du-Thumm
- Inventors: Lyndsay Schaeffer-Korbylo; Gregory Szewczyk; Laurence Du-Thumm
- Web page: https://patentgrep.com/patent/US8784779B2

## CPC

- A61K 8/35: Ketones, e.g. benzophenone
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/45: Colour indicators, e.g. pH- or Redox indicators
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Oral care compositions and methods are described in which the composition includes a chalcone color change component, which may be phenyl-3-methoxy-4-hydroxystyryl ketone. The color change component is induced to change colors by addition of saliva and/or by a change in pH of the composition. The composition and methods provide benefits including providing visual cues to the user.

## Claims

### Claim 1

A method of providing oral health benefits to an oral surface of a subject comprising contacting the oral surface of the subject with an oral care composition including phenyl-3-methoxy-4-hydroxystyryl ketone (CHAK4) as a color component and an orally acceptable carrier, wherein the oral care composition is allowed to contact saliva from the oral surface to effect a change in color of the oral care composition providing a feedback signal to the subject of the oral health benefits provided to the oral surface and a signal for when to cease contacting the oral surface with the oral care composition.

### Claim 2 (depends on 1)

The method of claim 1, wherein the oral care composition further comprises an antibacterial agent; and the oral health benefit is providing antibacterial activity.

### Claim 3 (depends on 2)

The method of claim 2, wherein the antibacterial agent is cetylpyridinium chloride and the amount of phenyl-3-methoxy-4-hydroxystyryl ketone (CHAK4) is from 0.01 wt. % to 10 wt. %.

### Claim 4 (depends on 3)

The method of claim 3, wherein the amount of phenyl-3-methoxy-4-hydroxystyryl ketone (CHAK4) is from 0.5 wt. % to 5 wt. % and the pH of the oral care composition is from 3.5 to 5.0.

### Claim 5 (depends on 4)

The method of claim 4, wherein the amount of phenyl-3-methoxy-4-hydroxystyryl ketone (CHAK4) is from 0.1 wt % to 1 wt. % and the color of the oral care composition changes from yellow to red after contacting saliva from the oral surface.

### Claim 6 (depends on 4)

The method of claim 4, wherein the oral care composition is a mouthwash.

### Claim 7 (depends on 4)

The method of claim 4, wherein the oral care composition is a dentifrice.