# US 8,784,668 B2 · Systems and methods for compensation of compliant behavior in regenerative dialysis systems > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,784,668 B2 - Document ID: US8784668B2 - Status: Granted - Kind: B2 - Application number: 12/902,702 - Filed: 2010-10-12 - Published: 2012-04-12 - Granted: 2014-07-22 - Earliest claimed: 2010-10-12 - Assignees: Fresenius Medical Care Holdings, Inc. - Applicants: Michael J Beiriger - Inventors: Michael J Beiriger - Web page: https://patentgrep.com/patent/US8784668B2 ## CPC - B01D 61/243: {Dialysis} - A61M 1/1696: {with dialysate regeneration} - B01D 61/30: Accessories; Auxiliary operation - B01D 61/32: Controlling or regulating - B01J 20/0211: {Compounds of Ti, Zr, Hf} - B01J 20/0277: {Carbonates of compounds other than those provided for in B01J20/043} - B01J 20/06: comprising oxides or hydroxides of metals not provided for in group B01J20/04 - B01J 20/08: comprising aluminium oxide or hydroxide; comprising bauxite - B01J 20/14: Diatomaceous earth - B01J 20/20: comprising free carbon; comprising carbon obtained by carbonising processes - B01J 20/28052: {Several layers of identical or different sorbents stacked in a housing, e.g. in a column} - B01J 20/3204: {Inorganic carriers, supports or substrates} - B01J 20/3274: {Proteins, nucleic acids, polysaccharides, antibodies or antigens} - B01J 20/3433: {of sorbents or filter aids other than those covered by B01J20/3408 - B01J20/3425} - B01J 39/05: in the strongly acidic form - A61M 2205/3393: by weighing the reservoir - B01D 2311/16: Flow or flux control - B01D 2311/2626: Absorption or adsorption - B01J 2220/62: In a cartridge - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS ## Abstract In a regenerative dialysis system, in a method for controlling a regenerative dialysis system, and in a controller for a regenerative dialysis system, an embodiment of the system comprises an input pump that pumps fresh dialysate fluid into a dialyzer at an input rate. An output pump pumps used dialysate fluid from the dialyzer at an output rate. An ultrafiltration rate of the system is related to the output rate relative to the input rate. A sorbent cartridge filters the used dialysate fluid to generate the fresh dialysate fluid. A controller controls the ultrafiltration rate of the system in response to a flow rate of the dialysate fluid through the sorbent cartridge. ## Claims ### Claim 1 A regenerative dialysis system, comprising: an input pump that pumps fresh dialysate fluid into a dialyzer at an input rate; an output pump that pumps used dialysate fluid from the dialyzer at an output rate, an ultrafiltration rate of the system being related to the output rate relative to the input rate; a sorbent cartridge that filters the used dialysate fluid to generate the fresh dialysate fluid; and a controller that controls the ultrafiltration rate of the system in response to a compliance model of the sorbent cartridge that provides a predefined model of compliant behavior related to the sorbent cartridge that is based on a relationship between a volume of dialysate fluid stored by the sorbent cartridge as a function of a flow rate of the dialysate fluid through the sorbent cartridge. ### Claim 2 (depends on 1) The system of claim 1 wherein the system further comprises: a reservoir that stores the fresh dialysate fluid; a scale that monitors the scale weight of the fresh dialysate fluid stored in the reservoir; and wherein the controller further controls the ultrafiltration rate in response to the scale weight of the fresh dialysate fluid in the reservoir. ### Claim 3 (depends on 2) The system of claim 2 wherein the controller further: calculates a dynamic weight of dialysate fluid stored in the sorbent cartridge in response to the flow rate of the dialysate fluid through the sorbent cartridge; calculates a corrected dialysate fluid weight by summing the dynamic weight and the scale weight; and controls the ultrafiltration rate of the system in response to the corrected dialysate fluid weight. ### Claim 4 (depends on 3) The system of claim 3 wherein the controller calculates the dynamic weight of the dialysate fluid over a time period of a treatment procedure. ### Claim 5 (depends on 3) The system of claim 3 wherein the controller further: calculates an absorption weight of dialysate fluid stored in the sorbent cartridge as a result of time-based absorption; and calculates the corrected dialysate fluid rate by further summing the absorption weight with the dynamic weight and the scale weight. ### Claim 6 (depends on 1) The system of claim 1 wherein the relationship between the volume of dialysate fluid stored by the sorbent cartridge as a function of flow rate of the dialysate fluid through the sorbent cartridge is linear. ### Claim 7 (depends on 1) The system of claim 1 wherein the relationship between the volume of dialysate fluid stored by the sorbent cartridge as a function of flow rate of the dialysate fluid through the sorbent cartridge is non-linear. ### Claim 8 (depends on 1) The system of claim 1 wherein the ultrafiltration rate is a rate at which fluid is removed from a patient at the dialyzer. ### Claim 9 (depends on 1) The system of claim 1 wherein the ultrafiltration rate of a dialysis procedure performed by the regenerative dialysis system is prescribed. ### Claim 10 A method of controlling ultrafiltration rate of a regenerative dialysis system, comprising: pumping fresh dialysate fluid into a dialyzer at an input rate; pumping used dialysate fluid from the dialyzer at an output rate, an ultrafiltration rate of the regenerative dialysis system being related to the output rate relative to the input rate; filtering the used dialysate fluid to generate the fresh dialysate fluid at a sorbent cartridge; and controlling the ultrafiltration rate of the regenerative dialysis system in response to a compliance model of the sorbent cartridge that provides a predefined model of compliant behavior related to the sorbent cartridge based on a relationship between a volume of dialysate fluid stored by the sorbent cartridge as a function of a flow rate of the dialysate fluid through the sorbent cartridge. ### Claim 11 (depends on 10) The method of claim 10 further comprising: storing the fresh dialysate fluid at a reservoir; monitoring a scale weight of the fresh dialysate fluid stored in the reservoir; and further controlling the ultrafiltration rate in response to the scale weight of the fresh dialysate fluid in the reservoir. ### Claim 12 (depends on 11) The method of claim 11 further comprising: calculating a dynamic weight of dialysate fluid stored in the sorbent cartridge in response to the flow rate of the dialysate fluid through the sorbent cartridge; and calculating the corrected dialysate fluid weight by summing the dynamic weight and the scale weight; and further controlling the ultrafiltration rate in response to the corrected dialysate fluid weight. ### Claim 13 (depends on 12) The method of claim 12 wherein calculating the dynamic weight of dialysate fluid stored in the sorbent cartridge is performed over a time period of a treatment procedure. ### Claim 14 (depends on 12) The method of claim 12 further comprising: calculating an absorption weight of dialysate fluid stored in the sorbent cartridge as a result of time-based absorption; and calculating the corrected dialysate fluid rate by further summing the absorption weight with the dynamic weight and the scale weight. ### Claim 15 (depends on 10) The method of claim 10 wherein the relationship between the volume of dialysate fluid stored by the sorbent cartridge as a function of flow rate of the dialysate fluid through the sorbent cartridge is linear. ### Claim 16 (depends on 10) The method of claim 10 wherein the relationship between the volume of dialysate fluid stored by the sorbent cartridge as a function of flow rate of the dialysate fluid through the sorbent cartridge is non-linear. ### Claim 17 (depends on 10) The method of claim 10 wherein the ultrafiltration rate is a rate at which fluid is removed from a patient at the dialyzer. ### Claim 18 (depends on 10) The method of claim 10 wherein the ultrafiltration rate of a dialysis procedure performed by the regenerative dialysis system is prescribed. ### Claim 19 A regenerative dialysis system, comprising: an input pump that pumps fresh dialysate fluid into a dialyzer at an input rate; an output pump that pumps used dialysate fluid from the dialyzer at an output rate, an ultrafiltration rate of the system being related to the output rate relative to the input rate; a sorbent cartridge that filters the used dialysate fluid to generate the fresh dialysate fluid; a controller that controls the ultrafiltration rate of the system in response to a flow rate of the dialysate fluid through the sorbent cartridge, wherein the controller controls the ultrafiltration rate of the system in response to a corrected dialysate fluid weight; a reservoir that stores the fresh dialysate fluid; a scale that monitors the scale weight of the fresh dialysate fluid stored in the reservoir, wherein the controller further controls the ultrafiltration rate in response to the scale weight of the fresh dialysate fluid in the reservoir, wherein the controller further: calculates a dynamic weight of dialysate fluid stored in the sorbent cartridge in response to the flow rate of the dialysate fluid through the sorbent cartridge; calculates the corrected dialysate fluid weight by summing the dynamic weight and the scale weight; calculates an absorption weight of dialysate fluid stored in the sorbent cartridge as a result of time-based absorption; and calculates the corrected dialysate fluid rate by further summing the absorption weight with the dynamic weight and the scale weight. ### Claim 20 A method of controlling ultrafiltration rate of a regenerative dialysis system, comprising: pumping fresh dialysate fluid into a dialyzer at an input rate; pumping used dialysate fluid from the dialyzer at an output rate, an ultrafiltration rate of the regenerative dialysis system being related to the output rate relative to the input rate; filtering the used dialysate fluid to generate the fresh dialysate fluid at a sorbent cartridge; controlling the ultrafiltration rate of the regenerative dialysis system in response to a flow rate of the dialysate fluid through the sorbent cartridge, and in response to a corrected dialysate fluid weight; storing the fresh dialysate fluid at a reservoir; monitoring the scale weight of the fresh dialysate fluid stored in the reservoir; further controlling the ultrafiltration rate in response to the scale weight of the fresh dialysate fluid in the reservoir; calculating a dynamic weight of dialysate fluid stored in the sorbent cartridge in response to the flow rate of the dialysate fluid through the sorbent cartridge; calculating the corrected dialysate fluid weight by summing the dynamic weight and the scale weight; calculating an absorption weight of dialysate fluid stored in the sorbent cartridge as a result of time-based absorption; and calculating the corrected dialysate fluid rate by further summing the absorption weight with the dynamic weight and the scale weight.