# US 8,784,630 B2 · Sample stacking method using on-line automatic solid phase extraction coupled to nonaqueous capillary electrophoresis and interface structure between solid-phase preconcentration cartridge and capillary therefor

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- Number: US 8,784,630 B2
- Document ID: US8784630B2
- Status: Granted
- Kind: B2
- Application number: 12/206,221
- Filed: 2008-09-08
- Published: 2009-04-02
- Granted: 2014-07-22
- Earliest claimed: 2007-09-28
- Assignees: Samsung Electronics Co., Ltd.; Seoul National University Industry Foundation
- Applicants: Doo Soo Chung; Lichun Liu; Kihwan Choi
- Inventors: Doo Soo Chung; Lichun Liu; Kihwan Choi
- Web page: https://patentgrep.com/patent/US8784630B2

## CPC

- G01N 27/44743: {Introducing samples}
- G01N 1/405: {by adsorption or absorption}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A sample stacking method using on-line automatic solid phase extraction coupled to nonaqueous capillary electrophoresis, and an interface structure between a solid-phase preconcentration cartridge and a capillary therefor. The sample analysis method using solid phase extraction coupled to nonaqueous capillary electrophoresis by connecting a solid-phase preconcentration cartridge with a capillary includes: extracting a sample on a solid phase; injecting an elution solvent at an outlet terminal of the capillary, the elution solution desorbing analytes adsorbed onto a solid-phase material of a solid-phase preconcentration cartridge; and injecting a nonaqueous buffer solution from the outlet terminal of the capillary to push the elution solvent to the solid-phase material.

## Claims

### Claim 1

An interface structure between a solid-phase preconcentration cartridge and a capillary for analyzing a sample by coupling solid phase extraction to capillary electrophoresis, wherein the solid-phase preconcentration cartridge comprises:
a polytetrafluoroethylene tubing sleeve, the sleeve being packed with a solid-phase material at one end;
an injection part of the capillary inserted into the other end of the tubing sleeve where the sample is injected into the tubing sleeve; and
wherein the capillary is the only capillary inserted into the tubing sleeve and further wherein the interface structure is positioned such that the full length of the capillary, other than the injection part of the capillary inserted into the tubing sleeve, protrudes from the tubing sleeve.

### Claim 2 (depends on 1)

The structure of claim 1, wherein the capillary inserted into the tubing sleeve has a length at least 3 times an outer diameter of the capillary.

### Claim 3 (depends on 1)

The structure of claim 1, wherein an inner diameter of the tubing is smaller than an outer diameter of the capillary to be inserted.