# US 8,784,465 B2 · Implantable medical devices

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- Number: US 8,784,465 B2
- Document ID: US8784465B2
- Status: Granted
- Kind: B2
- Application number: 12/940,388
- Filed: 2010-11-05
- Published: 2011-03-03
- Granted: 2014-07-22
- Earliest claimed: 2002-10-11
- Assignees: Boston Scientific Scimed, Inc.; University of Connecticut
- Applicants: Ronald A. Sahatjian; Francisca Tan; Patrick T. Mather; Changdeng Liu; Cheryl J. Campo
- Inventors: Ronald A. Sahatjian; Francisca Tan; Patrick T. Mather; Changdeng Liu; Cheryl J. Campo
- Web page: https://patentgrep.com/patent/US8784465B2

## CPC

- C08G 61/08: of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
- A61F 2/88: the wire-like elements formed as helical or spiral coils
- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F 2/915: with bands having a meander structure, adjacent bands being connected to each other
- A61L 29/14: Materials characterised by their function or physical properties {, e.g. lubricating compositions}
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- C08G 18/3893: {containing silicon}
- C08G 18/4277: {Caprolactone and/or substituted caprolactone}
- C08G 18/4833: {Polyethers containing oxyethylene units}
- C08L 65/00: Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain (C08L7/00 - C08L57/00, C08L61/00 take precedence); Compositions of derivatives of such polymers
- A61F 2002/8483: {Barbs}
- A61F 2002/91541: {Adjacent bands are arranged out of phase}
- A61F 2002/9528: {for retrieval of stents}
- A61F 2220/0016: with sharp anchoring protrusions, e.g. barbs, pins, spikes
- A61F 2250/0039: differing in diameter
- A61F 2250/0068: the pharmaceutical product being in a reservoir
- A61M 25/1027: {Making of balloon catheters}
- C08G 2230/00: Compositions for preparing biodegradable polymers
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.

## Claims

### Claim 1

A product comprising:
an endoprosthesis having a body formed of a non-bioabsorbable polymer comprising a cross-linked polycyclooctene, the polycyclooctene having been cross-linked while the endoprosthesis is in an expanded position to provide shape memory to the endoprosthesis, the endoprosthesis being designed for delivery into a body lumen and being in a collapsed state so that the endoprosthesis can be delivered into the body lumen, and wherein the endoprosthesis is capable of reverting from the collapsed state to the expanded state when warmed after delivery to a body lumen.

### Claim 2 (depends on 1)

The product of claim 1, wherein the body has a wall having a wall thickness and wherein the wall thickness is maintained if the endoprosthesis reverts from the collapsed state to the expanded state.

### Claim 3 (depends on 2)

The product of claim 2, wherein the change in the wall thickness is less than about 1%.

### Claim 4 (depends on 2)

The product of claim 2, wherein the wall thickness is from about 0.005 mm to about 5 mm.

### Claim 5 (depends on 1)

The product of claim 1, wherein the endoprosthesis is a stent.

### Claim 6 (depends on 1)

The product of claim 1, wherein the endoprosthesis is capable of reverting from the collapsed state to the expanded state at a temperature below 60° C.

### Claim 7 (depends on 1)

The product of claim 1, wherein the endoprosthesis is capable of reverting from the collapsed state to the expanded state at a temperature above 37° C.

### Claim 8 (depends on 1)

The product of claim 1, wherein only a portion of the endoprosthesis is in a collapsed state that is capable of reverting to an expanded state when warmed.

### Claim 9 (depends on 1)

The product of claim 1, wherein the polycyclooctene has been chemically cross-linked.

### Claim 10 (depends on 1)

The product of claim 1, wherein the endoprosthesis has a tubular shape.

### Claim 11 (depends on 1)

The product of claim 1, wherein the polycyclooctene has been radiation cross-linked.

### Claim 12 (depends on 1)

The product of claim 1, wherein the polycyclooctene exhibits a plateau in its plot of storage modulus as a function of temperature.

### Claim 13 (depends on 1)

The product of claim 1, wherein the endoprosthesis further includes radiopaque agent.

### Claim 14 (depends on 1)

The product of claim 1, wherein the endoprosthesis further includes a drug.

### Claim 15 (depends on 1)

The product of claim 1, wherein the body of the endoprosthesis is metal-free.

### Claim 16 (depends on 1)

The product of claim 1, wherein the body of the endoprosthesis consists of the cross-linked polycyclooctene.

### Claim 17

A product comprising:
a stent having a metal-free body formed of a non-bioabsorbable polymer comprising a cross-linked polycyclooctene, the polycyclooctene having been cross-linked while the stent is in an expanded position to provide shape memory to the stent, the stent being designed for delivery into a body lumen and being in a collapsed state so that the stent can be delivered into the body lumen, and wherein the stent is capable of reverting from the collapsed state to the expanded state when warmed after delivery to a body lumen.

### Claim 18 (depends on 17)

The product of claim 17, wherein the wall thickness is from about 0.005 mm to about 5 mm.

### Claim 19

A product comprising:
a stent having a body consisting of non-bioabsorbable cross-linked polycyclooctene, the polycyclooctene having been cross-linked while the stent is in an expanded position to provide shape memory to the stent, the stent being designed for delivery into a body lumen and being in a collapsed state so that the stent can be delivered into the body lumen, and wherein the stent is capable of reverting from the collapsed state to the expanded state when warmed after delivery to a body lumen.

### Claim 20 (depends on 19)

The product of claim 19, wherein the wall thickness is from about 0.005 mm to about 5 mm.