# US 8,784,464 B2 · Disposable cassette for intravascular heat exchange catheter

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- Number: US 8,784,464 B2
- Document ID: US8784464B2
- Status: Granted
- Kind: B2
- Application number: 13/471,381
- Filed: 2012-05-14
- Published: 2012-09-06
- Granted: 2014-07-22
- Earliest claimed: 1998-08-24
- Assignees: Zoll Circulation, Inc.
- Applicants: Timothy R. Machold; Nicole Denise Bloom; Alex T. Roth; David J. Scott; Jose Alejandro; Edward A. Oliver
- Inventors: Timothy R. Machold; Nicole Denise Bloom; Alex T. Roth; David J. Scott; Jose Alejandro; Edward A. Oliver
- Web page: https://patentgrep.com/patent/US8784464B2

## CPC

- A61F 7/12: Devices for heating or cooling internal body cavities
- A61F 7/0085: {Devices for generating hot or cold treatment fluids}
- A61F 7/123: {using a flexible balloon containing the thermal element}
- A61B 2017/00119: {alarm; indicating an abnormal situation}
- A61B 2017/00123: {and automatic shutdown}
- A61B 2017/22051: {with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation (A61B2017/22048, A61B2017/3486 take precedence)}
- A61F 7/10: Cooling bags, e.g. ice-bags
- A61F 2007/0054: {with a closed fluid circuit, e.g. hot water}
- A61F 2007/0096: {with a thermometer}
- A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels}
- A61M 5/44: having means for cooling or heating the devices or media
- A61M 25/1011: {Multiple balloon catheters}
- A61M 2025/1072: {having balloons with two or more compartments}
- A61M 2025/1086: {having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves}
- A61M 2205/127: with provisions for heating or cooling
- F28D 1/0341: {with U-flow or serpentine-flow inside the conduits}
- F28D 2021/005: {for medical applications}
- F28F 3/12: Elements constructed in the shape of a hollow panel, e.g. with channels {(F28D1/02, F28D1/03 take precedence)}
- F28F 9/0246: {Arrangements for connecting header boxes with flow lines}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- F28D: HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT (fluid heaters having heat generating means and heat transferring means F24H; furnaces F27; details of heat-exchange apparatus of general)
- F28F: DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION (water and air traps, air venting F16)

## Abstract

A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.

## Claims

### Claim 1

A disposable fluid circuit for pumping heat exchange fluid to a heat exchange catheter configured to be inserted into a person's vasculature, comprising:
an external heat exchanger having an input line and an output line, the output line configured to removably connect to a heat exchange catheter;
a vent having an output side fluidly connected to the input line of the external heat exchanger;
a fluid source;
a pump head having an inlet and an outlet, the inlet fluidly connected to the fluid source and to an output line configured to removably connect to the heat exchange catheter and the outlet fluidly connected to an input side of the vent, the pump head being a portion of tubing, the portion of tubing having an inlet side in fluid communication with the fluid source and the output line and an outlet side in fluid communication with the input side of the vent, the portion of tubing being adapted to insert into a body of a peristaltic pump; and
an air detector sensor fluidly connected to the external heat exchanger, the air detector sensor in communication with a master control unit for sensing air in heat exchange fluid flowing through the external heat exchanger and for generating a signal associated with sensed air in the fluid circuit and wherein the master control unit is responsive to the signal to control the peristaltic pump to stop pumping.

### Claim 2 (depends on 1)

The disposable fluid circuit of claim 1, wherein the peristaltic pump has a pump driver configured to compress the portion of tubing to move a fluid through the portion of tubing.

### Claim 3 (depends on 1)

The disposable fluid circuit of claim 1, wherein the fluid source is saline.

### Claim 4 (depends on 1)

The disposable fluid circuit of claim 1, wherein the external heat exchanger has a coil configuration.

### Claim 5 (depends on 1)

The disposable fluid circuit of claim 1, wherein the external heat exchanger is configured for insertion into a reusable housing.

### Claim 6 (depends on 1)

The disposable fluid circuit of claim 1, wherein the fluid source is filled with heat exchange fluid.

### Claim 7 (depends on 1)

The disposable fluid circuit of claim 1, wherein the heat exchanger, input line, output line, heat exchange catheter, vent and pump head form a fluid circuit, and the fluid circuit is pre-filled with fluid.

### Claim 8

A heat exchange circuit for exchanging heat with tissue of a patient, comprising:
an internal heat exchanger;
an external heat exchanger forming a fluid circuit with the internal heat exchanger by way of a length of tubing connecting the external heat exchanger with the internal heat exchanger;
a peristaltic pump for moving a heat exchange fluid through the fluid circuit, the peristaltic pump having a pump head defined by a portion of the length of the tubing engaged with a pump drive mechanism;
a vent in the fluid circuit, the vent being permeable to gas but not to fluid, the vent in communication with the atmosphere such that gas is removed from the fluid and exhausted to the atmosphere; and
an air detector sensor in communication with a master control unit for sensing air in the fluid circuit and for generating a signal associated with sensed air in the fluid circuit and wherein the master control unit is responsive to the signal to control the pump to stop pumping heat exchange fluid through the fluid circuit.

### Claim 9 (depends on 8)

A circuit as in claim 8, wherein the pump drive mechanism is mounted on the master control unit, the master control unit responsive to an input to activate the pump drive mechanism to pump fluid through the fluid circuit.

### Claim 10 (depends on 8)

A circuit as in claim 8, wherein the internal heat exchanger is a heat exchange catheter.