# US 8,784,461 B2 · Method and apparatus for optical stimulation of nerves and other animal tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,784,461 B2 - Document ID: US8784461B2 - Status: Granted - Kind: B2 - Application number: 13/966,134 - Filed: 2013-08-13 - Published: 2014-02-20 - Granted: 2014-07-22 - Earliest claimed: 2006-09-21 - Assignees: Lockheed Martin Corporation - Applicants: Lockheed Martin Corporation - Inventors: James S. Webb; Charles I. Miyake; Mark P. Bendett; Charles A. Lemaire - Web page: https://patentgrep.com/patent/US8784461B2 ## CPC - A61N 5/0622: {Optical stimulation for exciting neural tissue} - A61N 5/0618: {Psychological treatment} - A61N 2005/0644: {Handheld applicators} - A61N 2005/0651: {Diodes} - A61N 2005/0659: {infrared} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation. ## Claims ### Claim 1 A method comprising: providing a nerve-stimulation unit, the nerve-stimulation unit including a first nerve-stimulation-light-emitting source, a first visible-wavelength laser source, and a second visible-wavelength laser source, wherein the first nerve-stimulation-light-emitting source includes a first laser diode mounted in the nerve-stimulation unit; emitting, from the first visible-wavelength laser source, a first visible optical pointer signal at a first visible color wavelength, wherein the first visible color wavelength is visible to humans; emitting, from the second visible-wavelength laser source, a second visible optical pointer signal at a second visible color wavelength, wherein the second visible color wavelength is visible to humans; obtaining user input, and based on the user input, outputting from the first laser diode mounted in the nerve-stimulation unit, a first infrared laser beam having a third wavelength, wherein the third wavelength is different than the first visible color wavelength and the second visible color wavelength, wherein the first visible optical pointer signal and the second visible optical pointer signal together indicate a focus location of the first infrared laser beam at which the first infrared laser beam has a desired focus, and wherein at least the first visible optical pointer signal is non-coincident to the first infrared laser beam as the first visible optical pointer signal propagates through an exit surface of the nerve-stimulation unit; focusing the first infrared laser beam to the focus location, wherein the focussed first infrared laser beam is configured to directly optically stimulate an action potential response in a neural tissue of an animal subject; and stimulating the neural tissue, wherein the stimulating includes adjusting the focusing of the first infrared laser beam, by observing the first visible optical pointer signal and the second visible optical pointer signal, such that the focused first infrared laser beam triggers the action potential response in the neural tissue. ### Claim 2 (depends on 1) The method of claim 1, further comprising delivering a liquid to the neural tissue of the animal subject from the nerve-stimulation unit. ### Claim 3 (depends on 1) The method of claim 1, wherein the focusing of the first infrared laser beam includes serially focusing the first infrared laser beam through a plurality of optical focus elements. ### Claim 4 (depends on 1) The method of claim 1, wherein the stimulating of the neural tissue further includes focusing the first infrared laser beam to an area sufficiently small to stimulate just a subset of nerves within a nerve bundle. ### Claim 5 (depends on 1) The method of claim 1, wherein the emitting of the first visible optical pointer signal includes emitting visible red light, and wherein the emitting of the second visible optical pointer signal includes emitting visible blue light. ### Claim 6 (depends on 1) The method of claim 1, further comprising crossing the first visible optical pointer signal with the second visible optical pointer signal at the focus location of the first infrared laser beam such that the first visible optical pointer signal and the second visible optical pointer signal coincide with each other at the focus location of the first infrared laser beam. ### Claim 7 (depends on 1) The method of claim 1, wherein the outputting of the first infrared laser beam further includes supplying electrical power from a battery to the laser diode. ### Claim 8 (depends on 1) The method of claim 1, wherein the second visible color wavelength is different than the first visible color wavelength. ### Claim 9 (depends on 1) The method of claim 1, further comprising: providing a tissue-ablation laser source that selectively delivers a pulsed tissue-ablation optical signal at a fourth wavelength that ablates tissue of the animal subject; detecting locations of one or more nerves of the animal subject; projecting a map of the located one or more nerves; and suppressing output from the tissue-ablation laser source when in a vicinity of the detected locations of the one or more nerves. ### Claim 10 (depends on 1) The method of claim 1, further comprising incorporating optics into a disposable sheath applied to the nerve-stimulation unit, wherein the focusing includes transmitting the first infrared laser beam through the optics. ### Claim 11 A method comprising: providing a tissue-interaction unit, the tissue-interaction unit including a tissue-interaction laser source, a first visible-wavelength laser source, and a second visible-wavelength laser source; emitting, from the first visible-wavelength laser source, a first visible optical pointer signal at a first visible color wavelength, wherein the first visible color wavelength is visible to humans; emitting, from the second visible-wavelength laser source, a second visible optical pointer signal at a second visible color wavelength, wherein the second visible color wavelength is visible to humans; obtaining user input, and based on the user input, outputting from the tissue-interaction laser source, a pulsed tissue-interaction optical signal having a third wavelength, wherein the third wavelength is different than the first visible color wavelength and the second visible color wavelength, wherein the first visible optical pointer signal and the second visible optical pointer signal together indicate a focus location of the pulsed tissue-interaction optical signal at which the pulsed tissue-interaction optical signal has a desired focus, and wherein at least the first visible optical pointer signal is non-coincident to the pulsed tissue-interaction optical signal as the first optical pointer signal propagates through an exit surface of the tissue-interaction unit; and focusing the pulsed tissue-interaction optical signal to the focus location such that the focussed pulsed tissue-interaction optical signal causes at least one result selected from the set consisting of: (triggering a nerve-action potential in a nerve of an animal subject, and ablating tissue of the animal subject). ### Claim 12 (depends on 10) The method of claim 10, further comprising delivering a liquid to the neural tissue of the animal subject from the tissue-interaction unit. ### Claim 13 (depends on 10) The method of claim 10, wherein the focusing of the pulsed optical signal includes serially focusing the pulsed optical signal through a plurality of optical focus elements. ### Claim 14 (depends on 10) The method of claim 10, wherein the at least one result is triggering a nerve-action potential in the nerve of the animal subject, and wherein the triggering of the nerve-action potential includes further focusing the pulsed optical signal to an area sufficiently small to stimulate just a subset of nerves within a nerve bundle. ### Claim 15 (depends on 10) The method of claim 10, wherein the emitting of the first visible optical pointer signal includes emitting visible red light, and wherein the emitting of the second visible optical pointer signal includes emitting visible blue light. ### Claim 16 (depends on 10) The method of claim 10, further comprising crossing the first visible optical pointer signal with the second visible optical pointer signal at the focus location of the pulsed tissue-interaction optical signal such that the first visible optical pointer signal and the second visible optical pointer signal coincide with each other at the focus location of the pulsed tissue-interaction optical signal. ### Claim 17 (depends on 10) The method of claim 10, wherein the outputting of the pulsed optical signal further includes supplying electrical power from a battery to the tissue-interaction laser source. ### Claim 18 (depends on 10) The method of claim 10, wherein the second visible color wavelength is different than the first visible color wavelength. ### Claim 19 (depends on 10) The method of claim 10, wherein the at least one result is ablating tissue of the animal subject, the method further comprising: detecting locations of one or more nerves of the animal subject; projecting a map of the located one or more nerves; suppressing the ablating of the tissue of the animal subject when in a vicinity of the detected locations of the one or more nerves; and incorporating optics into a disposable sheath applied to the tissue-interaction unit, wherein the focusing includes transmitting the pulsed optical signal through the optics. ### Claim 20 A method comprising: providing a tissue-ablation unit, the tissue-ablation unit including a tissue-ablation laser source, a first visible-wavelength laser source, and a second visible-wavelength laser source; emitting, from the first visible-wavelength laser source, a first visible optical pointer signal at a first visible color wavelength, wherein the first visible color wavelength is visible to humans; emitting, from the second visible-wavelength laser source, a second visible optical pointer signal at a second visible color wavelength, wherein the second visible color wavelength is visible to humans; obtaining user input, and based on the user input, outputting from the tissue-ablation laser source, a pulsed tissue-ablation optical signal having a third wavelength, wherein the third wavelength is different than the first visible color wavelength and the second visible color wavelength, wherein the first visible optical pointer signal and the second visible optical pointer signal together indicate a focus location of the pulsed tissue-ablation optical signal at which the pulsed tissue-ablation optical signal has a desired focus, and wherein at least the first visible optical pointer signal is non-coincident to the pulsed tissue-ablation optical signal as the first optical pointer signal propagates through an exit surface of the tissue-interaction unit; and focusing the pulsed tissue-ablation optical signal to the focus location such that the focussed pulsed tissue-ablation optical signal ablates tissue of the animal subject.