# US 8,784,446 B1 · Circumferentially offset variable porosity devices

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- Number: US 8,784,446 B1
- Document ID: US8784446B1
- Status: Granted
- Kind: B1
- Application number: 14/224,775
- Filed: 2014-03-25
- Granted: 2014-07-22
- Earliest claimed: 2013-07-29
- Assignees: Insera Therapeutics, Inc.
- Applicants: Insera Therapeutics, Inc.
- Inventors: Vallabh Janardhan; Vikram Janardhan
- Web page: https://patentgrep.com/patent/US8784446B1

## CPC

- A61B 17/22032: {having inflatable gripping elements (balloon catheters A61M25/10)}
- A61B 17/12109: {in a blood vessel}
- A61B 17/12113: {within an aneurysm}
- A61B 17/12122: {within the heart (for closing a cardiac septal defect A61B17/0057)}
- A61B 17/12172: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61B 17/22: Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B 17/22031: {Gripping instruments, e.g. forceps, for removing or smashing calculi (A61B17/221 takes precedence)}
- A61B 17/221: Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)}
- A61B 17/32056: {Surgical snare instruments (for removing or smashing calculi A61B2017/2212; tonsillotomes A61B17/26)}
- A61B 17/3207: Atherectomy devices {working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions (A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016)}
- A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers}
- A61M 1/74: {Suction control (underwater drainage A61M1/61)}
- A61M 1/84: {Drainage tubes; Aspiration tips (for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32)}
- A61M 25/0023: {by the form of the lumen, e.g. cross-section, variable diameter}
- A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00})
- A61M 29/00: Dilators with or without means for introducing media, e.g. remedies
- B23K 26/083: {Devices involving movement of the workpiece in at least one axial direction}
- B23K 26/14: using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor (B23K26/12 takes precedence)
- B23K 26/142: for the removal of by-products
- B23K 26/1435: {involving specially adapted flow-control means}
- B23K 26/146: the fluid stream containing a liquid
- B23K 26/20: Bonding (soldering by means of radiant energy B23K1/005)
- B23K 26/38: by boring or cutting
- B26F 3/004: {by means of a fluid jet (methods for use of abrasive blasting for cutting B24C1/045; guns for abrasive fluid jets B24C5/02; perforating by non-mechanical means, e.g. by fluid jet B26F1/26)}
- D04C 1/06: Braid or lace serving particular purposes
- D04C 1/12: Cords, lines, or tows
- D04C 3/48: Auxiliary devices
- A61B 2017/00526: {Methods of manufacturing}
- A61B 2017/00575: {for closure at remote site, e.g. closing atrial septum defects}
- A61B 2017/00592: {Elastic or resilient implements}
- A61B 2017/00606: {Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening}
- A61B 2017/00641: {for closing fistulae, e.g. anorectal fistulae}
- A61B 2017/00778: {Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence)}
- A61B 2017/22001: {Angioplasty, e.g. PCTA}
- A61B 2017/22002: {preventing restenosis}
- A61B 2017/22034: {for gripping the obstruction or the tissue part from inside}
- A61B 2017/22035: {for retrieving or repositioning foreign objects}
- A61B 2017/22067: {Blocking; Occlusion (A61B2017/22054 takes precedence)}
- A61B 2090/3966: {Radiopaque markers visible in an X-ray image}
- A61F 2/011: {Instruments for their placement or removal}
- A61F 2002/018: {made from tubes or sheets of material, e.g. by etching or laser-cutting}
- A61M 2025/0042: {Microcatheters, cannula or the like having outside diameters around 1 mm or less}
- A61M 2202/06: Solids
- A61M 2207/10: Device therefor
- A61M 2210/12: Blood circulatory system
- D10B 2403/0333: with tubular portions of variable diameter or distinct axial orientation
- D10B 2509/06: Vascular grafts; stents
- Y10T 29/49913: by constricting outer annulus
- Y10T 29/49995: Shaping one-piece blank by removing material
- Y10T 82/2521: Bar feeder
- Y10T 137/8376: Combined
- Y10T 137/85954: Closed circulating system
- Y10T 156/10: Methods of surface bonding and/or assembly therefor
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B23K: SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B26F: PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING (marking-out, perforating or making buttonholes A41H25/00; shoemaking A43D; surgery A61B; punching metal B21D; drilling metal B23B; cutting of metal by applying heat locally, e.g. flame cutting, B23K; cutting by abrasive fluid jets B24C5/02; details common to machines for severing B26D; drilling wood B27C; drilling stone B28D; working of plastics or substances in a plastic state B29; making boxes, cartons, envelopes or bags, of paper or similarly worked materials, e.g. metal foil, B31B; of glass C03B; of leather C14B; of textile materials D06H; for light guides G02B6/25; of tickets G07B)
- D04C: BRAIDING OR MANUFACTURE OF LACE, INCLUDING BOBBIN-NET OR CARBONISED LACE; BRAIDING MACHINES; BRAID; LACE (machines for making soles from strips of material A43D29/00; cane working B27J1/00)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

An implantable device for treating a vascular cavity or vascular malformation may include a plurality of wires woven to form a textile structure expandable from a compressed state to an expanded state. The textile structure may have a longitudinal axis and may include, in the expanded state, a first longitudinal segment, a second longitudinal segment, and a lumen configured to allow perfusion of blood through the textile structure parallel to the longitudinal axis. The first longitudinal segment may include a first circumferential portion including a first braid angle and a second circumferential portion opposite the first circumferential portion and including a second braid angle greater than the first braid angle. At least one of the first longitudinal segment and the second longitudinal segment may comprise a bulb.

## Claims

### Claim 1

An implantable device for treating a vascular cavity or vascular malformation, the device comprising:
a plurality of wires woven to form a textile structure expandable from a compressed state to an expanded state,
the textile structure having a longitudinal axis and comprising, in the expanded state:
a first bulb having a spherical shape,
a second bulb having an elongate shape, the second bulb comprising:
a first circumferential portion comprising a first braid angle, and
a second circumferential portion comprising a second braid angle greater than the first braid angle, the second circumferential portion circumferentially opposite the first circumferential portion,
a third bulb having a spherical shape,
the second bulb between the first bulb and the third bulb along the longitudinal axis,
a first neck between the first bulb and the second bulb along the longitudinal axis, and
a second neck between the second bulb and the third bulb along the longitudinal axis.

### Claim 2 (depends on 1)

The device of claim 1, wherein the first bulb comprises a third braid angle and the third bulb comprises a fourth braid angle, the third braid angle less than the second braid angle, the fourth braid angle less than the second braid angle.

### Claim 3 (depends on 1)

The device of claim 1, wherein the textile structure further comprises, in the expanded state:
a third neck, the first bulb between the first neck and the third neck along the longitudinal axis, and
a fourth neck, the third bulb between the second neck and the fourth neck along the longitudinal axis.

### Claim 4 (depends on 1)

The device of claim 1, wherein the first braid angle is between 0° and 90° and wherein the second braid angle is between 91° and 180°.

### Claim 5

An implantable device for treating a vascular cavity or vascular malformation, the device comprising:
a plurality of wires woven to form a textile structure expandable from a compressed state to an expanded state,
the textile structure having a longitudinal axis and comprising, in the expanded state:
a first bulb having a spherical shape,
a second bulb having an elongate shape, the second bulb comprising:
a first circumferential portion comprising a polymer, and
a second circumferential portion circumferentially opposite the first circumferential portion, the second circumferential portion being free of the polymer coating,
a third bulb having a spherical shape,
the second bulb between the first bulb and the third bulb along the longitudinal axis,
a first neck between the first bulb and the second bulb along the longitudinal axis, and
a second neck between the second bulb and the third bulb along the longitudinal axis.

### Claim 6 (depends on 5)

The device of claim 5, wherein the polymer coating is non-porous.

### Claim 7 (depends on 5)

The device of claim 5, wherein the polymer coating comprises radiopaque material.

### Claim 8 (depends on 5)

The device of claim 5, wherein the polymer coating is coated onto the first circumferential portion of the third bulb, an inner surface of the first circumferential portion of the second bulb being free of the polymer coating.

### Claim 9 (depends on 5)

The device of claim 5, wherein the textile structure further comprises, in the expanded state, a third neck, the first bulb between the first neck and the third neck along the longitudinal axis.

### Claim 10 (depends on 5)

The device of claim 5, wherein the first bulb has a first diameter, the second bulb has the first diameter, and the third bulb has the first diameter.

### Claim 11

An implantable device for treating a vascular cavity or vascular malformation, the device comprising:
a plurality of wires woven to form a textile structure expandable from a compressed state to an expanded state,
the textile structure having a longitudinal axis and comprising, in the expanded state:
a first longitudinal segment comprising:
a first circumferential portion comprising a first braid angle, and
a second circumferential portion comprising a second braid angle greater than the first braid angle, the second circumferential portion circumferentially opposite the first circumferential portion,
a second longitudinal segment,
at least one of the first longitudinal segment and the second longitudinal segment comprising a bulb, and
a lumen configured to allow perfusion of blood through the textile structure parallel to the longitudinal axis.

### Claim 12 (depends on 11)

The device of claim 11, wherein the first longitudinal segment comprises the bulb.

### Claim 13 (depends on 11)

The device of claim 11, wherein the second longitudinal segment comprises the bulb.

### Claim 14 (depends on 11)

The device of claim 11, wherein the first circumferential portion is configured to allow perfusion of blood through the first circumferential portion at a first rate and wherein the second circumferential portion is configured to allow perfusion of blood through the second circumferential portion at a second rate less than the first rate.

### Claim 15 (depends on 11)

The device of claim 11, wherein the textile structure further comprises, in the expanded state, a third longitudinal segment, the first longitudinal segment between the second longitudinal segment and the third longitudinal segment.

### Claim 16 (depends on 15)

The device of claim 15, wherein the first longitudinal segment comprises the bulb, the second longitudinal segment comprises a second bulb, and the third longitudinal segment comprises a third bulb, and wherein the textile structure comprises a first neck longitudinally between the bulb and the second bulb and a second neck longitudinally between the bulb and the third bulb.

### Claim 17 (depends on 16)

The device of claim 16, wherein the second bulb is spherical, the bulb is elongate, and the third bulb is spherical.

### Claim 18 (depends on 17)

The device of claim 17, wherein the second bulb has a first diameter, the bulb has a second diameter less than the first diameter, and the third bulb has a third diameter less than the second diameter.

### Claim 19 (depends on 16)

The device of claim 16, wherein the second bulb is spherical and has a first diameter, the bulb is elongate and has a second diameter less than the first diameter, and the third bulb is spherical and has a third diameter less than the second diameter.

### Claim 20 (depends on 16)

The device of claim 16, wherein the second bulb has a first diameter, the bulb has a second diameter less than the first diameter, and the third bulb has a third diameter less than the second diameter.