# US 8,784,384 B2 · Frozen compositions and array devices thereof

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- Number: US 8,784,384 B2
- Document ID: US8784384B2
- Status: Granted
- Kind: B2
- Application number: 12/586,073
- Filed: 2009-09-15
- Published: 2010-05-13
- Granted: 2014-07-22
- Earliest claimed: 2008-10-31
- Assignees: The Invention Science Fund I, LLC
- Applicants: Edward S. Boyden; Daniel B. Cook; Roderick A. Hyde; Eric C. Leuthardt; Nathan P. Myhrvold; Elizabeth A. Sweeney; Lowell L. Wood, Jr.
- Inventors: Edward S. Boyden; Daniel B. Cook; Roderick A. Hyde; Eric C. Leuthardt; Nathan P. Myhrvold; Elizabeth A. Sweeney; Lowell L. Wood, Jr.
- Web page: https://patentgrep.com/patent/US8784384B2

## CPC

- G16H 30/40: for processing medical images, e.g. editing
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0021: {Intradermal administration, e.g. through microneedle arrays or needleless injectors}
- A61K 9/007: {Pulmonary tract; Aromatherapy}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)}
- A61K 9/143: {with inorganic compounds}
- A61K 9/1611: {Inorganic compounds}
- A61K 9/1641: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers}
- A61K 9/1664: {Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/1617)}
- A61K 9/1688: {resulting in pure drug agglomerate optionally containing up to 5% of excipient}
- A61K 9/19: lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)}
- A61K 9/209: {containing drug in at least two layers or in the core and in at least one outer layer}
- A61K 9/2095: {Tabletting processes}
- A61K 9/2866: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 31/337: having four-membered rings, e.g. taxol
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K 31/7088: Compounds having three or more nucleosides or nucleotides
- A61K 31/74: Synthetic polymeric materials
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 38/38: Albumins
- A61K 38/4833: {Thrombin (3.4.21.5)}
- A61K 39/12: Viral antigens
- A61K 39/145: Orthomyxoviridae, e.g. influenza virus
- A61K 41/0004: {Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61M 37/0015: {by using microneedles}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 31/16: for influenza or rhinoviruses
- A61P 35/00: Antineoplastic agents
- C07K 16/22: against growth factors {; against growth regulators}
- C07K 16/283: {against Fc-receptors, e.g. CD16, CD32, CD64 (CD23 C07K16/2851)}
- C07K 16/2842: {against integrin beta1-subunit-containing molecules, e.g. CD29, CD49}
- C07K 16/2878: {against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95}
- C07K 16/30: from tumour cells
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G16H 50/50: for simulation or modelling of medical disorders
- A61K 31/505: Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/59: Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K 38/4886: {Metalloendopeptidases (3.4.24), e.g. collagenase}
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- A61K 2039/505: {comprising antibodies}
- A61K 2039/54: {characterised by the route of administration}
- A61M 2037/0023: {Drug applicators using microneedles}
- A61M 2037/003: {having a lumen}
- A61M 2205/02: characterised by a particular materials
- B33Y 80/00: Products made by additive manufacturing
- C12N 2760/16034: Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- G16H 20/10: relating to drugs or medications, e.g. for ensuring correct administration to patients
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
- Y10T 83/222: With receptacle or support for cut product
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

## Claims

### Claim 1

An array device, comprising:
a support structure having a surface; and
a plurality of sterile frozen ice therapeutic composition piercing implements extending substantially outward from the support structure, the implements consisting essentially of sterile ice and including at least one internal channel containing at least one anti-inflammatory agent.

### Claim 2 (depends on 1)

The array device of claim 1, wherein the plurality of sterile frozen piercing implements extends substantially perpendicular to the support structure.

### Claim 3 (depends on 1)

The array device of claim 1, wherein the support structure includes at least one frozen composition.

### Claim 4 (depends on 1)

The array device of claim 1, wherein the support structure is at least partially frozen.

### Claim 5 (depends on 1)

The array device of claim 1, wherein the support structure and at least one frozen piercing implement of the plurality of frozen piercing implements include at least one common constituent.

### Claim 6 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements are positioned substantially parallel to each other.

### Claim 7 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements are positioned substantially in a predetermined spatial pattern.

### Claim 8 (depends on 7)

The array device of claim 7, wherein the predetermined spatial pattern is at least partially periodic.

### Claim 9 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements include approximately the same length.

### Claim 10 (depends on 1)

The array device of claim 1, wherein the length of a frozen piercing implement corresponds to the position or location of the frozen piercing implement in the array device.

### Claim 11 (depends on 1)

The array device of claim 1, wherein the length of a frozen piercing implement is actuatable.

### Claim 12 (depends on 1)

The array device of claim 1, wherein at least one frozen piercing implement is configured to be deactivated.

### Claim 13 (depends on 12)

The array device of claim 12, wherein the at least one frozen piercing implement is configured to be deactivated by at least one component of the array device or the frozen piercing implement.

### Claim 14 (depends on 13)

The array device of claim 13, wherein the at least one frozen piercing implement is configured to be deactivated by thermal transfer to the at least one frozen piercing implement.

### Claim 15 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements is positioned as at least a portion of a fluidic or injection device.

### Claim 16 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements is positioned in fluid communication with at least one compartment configured to be mechanically regulated.

### Claim 17 (depends on 1)

The array device of claim 1, wherein at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter.

### Claim 18 (depends on 1)

The array device of claim 1, wherein at least one frozen piercing implement of the plurality further includes at least one vitamin, mineral, cell growth promoter, angiogenic factor, hormone, cytokine, or anesthetic agent.

### Claim 19 (depends on 18)

The array device of claim 18, wherein each frozen piercing implement of the plurality includes at least one agent different than the agent of every other frozen piercing implement of the plurality.

### Claim 20 (depends on 18)

The array device of claim 18, wherein the device includes at least two different agents.

### Claim 21 (depends on 1)

The array device of claim 1, wherein the frozen piercing implement is configured for delivering the at least one agent.

### Claim 22 (depends on 1)

The array device of claim 1, wherein at least two frozen piercing implements of the plurality of frozen piercing implements have at least one agent in common.

### Claim 23 (depends on 1)

The array device of claim 1, wherein each frozen piercing implement of the plurality of frozen piercing implements is different from every other piercing implement by varying one or more of: size of implement, shape of implement, or constitution of implement.

### Claim 24 (depends on 1)

The array device of claim 1, wherein at least two frozen piercing implements of the plurality of frozen piercing implement differ in one or more of: size of implement, shape of implement, or constitution of implement.

### Claim 25 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements are arranged in at least one configuration including a regular or irregular shape.

### Claim 26 (depends on 1)

The array device of claim 1, wherein the plurality of frozen piercing implements are arranged in at least one configuration including at least one of a rectangle, square, circle, triangle, or polygon.

### Claim 27 (depends on 1)

The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one functionalized surface.

### Claim 28 (depends on 27)

The array device of claim 27, wherein the at least one functionalized surface includes one or more functionalities including one or more of charge functionality, hydrophobic functionality, hydrophilic functionality, chemically reactive functionality, or wettability.

### Claim 29 (depends on 27)

The array device of claim 27, wherein the at least one functionalized surface includes one or more functional groups including at least one of an agent, alcohol, hydroxyl, amine, aldehyde, dye, ketone, carbonyl, thiol, alkoxysilane, phosphate, carboxyl, carboxylic acid, carboxylate, nucleic acid, amino acid, polypeptide, protein, lipid, carbohydrate, metal, —NH3+, —COOH, —COO—, —SO3, CH2N+(CH3)3, —(CH2)xCH3, —C((CH2)xCF3)3, —CH2N(C2H5)2, —NH2, —(CH2)xCOOH, —(OCH2CH2)xCH3, —SiOH, or —OH.

### Claim 30 (depends on 27)

The array device of claim 27, wherein the at least one functionalized surface includes at least part of an outer surface.

### Claim 31 (depends on 27)

The array device of claim 27, wherein the at least one functionalized surface includes at least part of an inner surface.

### Claim 32 (depends on 1)

The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one inlet port.

### Claim 33 (depends on 1)

The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one outlet port.

### Claim 34 (depends on 1)

The array device of claim 1, wherein at least one implement of the plurality of frozen piercing implements includes at least one sensor.

### Claim 35 (depends on 1)

The array device of claim 1, wherein at least one implement of the plurality of frozen piercing implements is configured for extracting at least one material from at least one substrate.

### Claim 36 (depends on 1)

The array device of claim 1, further including at least one attachment component configured to secure the array device to at least one substrate.

### Claim 37 (depends on 36)

The array device of claim 36, wherein the at least one attachment component includes at least one adhesive material.

### Claim 38 (depends on 1)

The array device of claim 1, wherein the device is configured to substantially form a patch.

### Claim 39 (depends on 1)

The array device of claim 1, further including at least one compartment.

### Claim 40 (depends on 39)

The array device of claim 39, wherein the at least one compartment includes at least one syringe or at least one valve.

### Claim 41 (depends on 39)

The array device of claim 39, wherein the at least one compartment is configured to hold at least one material extracted from at least one substrate.

### Claim 42 (depends on 1)

The array device of claim 1, further including at least one of an adhesive agent, reinforcement agent, abrasive, biological remodeling agent, or explosive material.

### Claim 43 (depends on 1)

The array device of claim 1, further including at least one compartment in fluid communication with at least one frozen piercing implement of the plurality of frozen piercing implements.

### Claim 44 (depends on 43)

The array device of claim 43, wherein the at least one compartment is configured for holding at least one agent.

### Claim 45 (depends on 43)

The array device of claim 43, wherein the at least one compartment is configured for holding at least one cryogenic substance.

### Claim 46 (depends on 43)

The array device of claim 43, further including a plurality of compartments in fluid communication with at least one frozen piercing implement of the plurality of frozen piercing implements.

### Claim 47 (depends on 46)

The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one different substance from at least one second compartment.

### Claim 48 (depends on 46)

The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one first agent, wherein the at least one first agent is different from at least one other agent located in at least one second compartment.

### Claim 49 (depends on 46)

The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one first agent, and at least one second compartment configured to hold a pharmaceutically acceptable carrier or excipient.

### Claim 50 (depends on 1)

The array device of claim 1, wherein the array device is in electronic communication with at least one computing device.

### Claim 51 (depends on 1)

The array device of claim 1, further including a heater.

### Claim 52

An array device, comprising:
a support structure having a surface;
a plurality of sterile frozen ice therapeutic composition piercing implements consisting essentially of sterile ice and extending substantially outward from the support structure, at least one of the plurality of sterile frozen ice therapeutic composition piercing implements including one or more antibiotics;
and an attachment component configured for securing to a biological tissue.