# US 8,784,380 B2 · Method and device for painless injection of medication

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- Number: US 8,784,380 B2
- Document ID: US8784380B2
- Status: Granted
- Kind: B2
- Application number: 12/630,996
- Filed: 2009-12-04
- Published: 2010-03-25
- Granted: 2014-07-22
- Earliest claimed: 2002-09-12
- Assignees: Children's Hospital Medical Center
- Applicants: Eric James Wall
- Inventors: Eric James Wall
- Web page: https://patentgrep.com/patent/US8784380B2

## CPC

- A61M 5/422: {Desensitising skin}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0021: {Intradermal administration, e.g. through microneedle arrays or needleless injectors}
- A61M 5/14248: {of the skin patch type}
- A61M 5/14586: {pressurised by means of a flexible diaphragm}
- A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)}
- A61M 5/14526: {the piston being actuated by fluid pressure}
- A61M 5/1454: {spring-actuated, e.g. by a clockwork}
- A61M 5/1782: {Devices aiding filling of syringes in situ (combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003)}
- A61M 5/2046: {Media being expelled from injector by gas generation, e.g. explosive charge}
- A61M 5/2053: {Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155)}
- A61M 5/206: {with automatic needle insertion}
- A61M 5/282: {by compression of deformable ampoule or carpule wall}
- A61M 5/3257: {Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means}
- A61M 5/326: {Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user}
- A61M 5/46: having means for controlling depth of insertion
- A61M 2005/14252: {with needle insertion means}
- A61M 2005/1426: {with means for preventing access to the needle after use}
- A61M 2005/2073: {preventing premature release, e.g. by making use of a safety lock}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method for providing a substantially painless injection of medication into a patient, including inserting an injection needle having an outside diameter greater than 0.20 mm and less than about 0.38 mm, and injecting a medicament through the needle and into the patient at a substantially constant volumetric flow rate of about 0.05 μL/s to about 50 μL/s that provides a painless injection. The method does not require the use of an anesthetic or that the medical personnel to spend a substantial amount of time performing the injection procedure, is relatively simple and inexpensive to perform and operate, and provides a relatively high degree of safety for both the medical personnel and for the patient.

## Claims

### Claim 1

A self-contained device for injecting a medicament, comprising:
a) a housing that includes a base,
b) an injection needle disposed within the housing and having an injection end configured for insertion into the skin of a patient,
c) a reservoir containing a liquid medicament and configured for liquid communication with the injection needle,
d) a means for injecting the medicament from the reservoir to the injection end of the needle at a substantially constant volumetric flow rate of about 0.05 μL/s to about 50 μL/s, and
e) a bandage comprising a base-contacting surface releasably affixed to the base of the housing for semi-permanent attachment of the bandage to the base of the device, and a skin-contacting surface that comprises an affixment for temporary securement of the bandage to the skin.

### Claim 2 (depends on 1)

The device according to claim 1 wherein the affixment of the bandage to the skin is greater than the affixment of the bandage to the base, whereby when the attached device is removed from the skin, the bandage detaches from the base of the device and remains attached to the skin.

### Claim 3 (depends on 2)

The device according to claim 2 wherein the bandage comprises a pad portion through which the injection needle penetrates when moving between its first and second positions.

### Claim 4 (depends on 3)

The device according to claim 3 wherein the pad portion is selected from the group consisting of a gauze, a wound dressing, and an absorbent material.

### Claim 5 (depends on 4)

The device according to claim 4 wherein the affixment of the bandage to the skin comprises an attachment portion that includes a second adhesive, wherein the attachment portion surrounds the pad.

### Claim 6 (depends on 2)

The device according to claim 2 wherein the affixment of the bandage to the base of the device comprises a first adhesive on the base of the device, and the affixment of the bandage to the skin comprises a second adhesive of the skin-contacting surface of the bandage.

### Claim 7 (depends on 2)

The device according to claim 2 wherein the second affixment attaches the device to the skin without requiring medical personnel to hold the device.

### Claim 8 (depends on 2)

The device according to claim 2 wherein the affixment of the bandage to the base comprises a first adhesive on the base of the device having an adhesion to the base that is greater than its adhesion to the attachment portion of the device-contacting side of the bandage.

### Claim 9 (depends on 1)

The device according to claim 1 further comprising a means for inserting an injection end of the injection needle between a first position wherein injection end is within the housing and a second position wherein the injection end extends outwardly from the base and is inserted into the skin of the patient.

### Claim 10 (depends on 9)

The device according to claim 9 further comprising a means for preselecting the depth of extension of the injection end of the needle at its second position.

### Claim 11 (depends on 9)

The device according to claim 9 further comprising a means for retracting the injection end of the injection needle from the second position and a third position within the housing.

### Claim 12 (depends on 1)

The device according to claim 1 wherein the substantially constant volumetric flow rate is about 0.5 μL/s to about 20 μL/s.

### Claim 13 (depends on 12)

The device according to claim 12 wherein the substantially constant volumetric flow rate is about 1 μL/s to about 4 μL/s.

### Claim 14 (depends on 1)

The device according to claim 1 wherein the needle has an outside diameter greater than 0.20 mm and less than about 0.38 mm.

### Claim 15 (depends on 14)

The device according to claim 14 wherein the needle is selected from the group consisting of a 28 gauge needle, a 30 gauge needle, and a 32 gauge needle.