# US 8,784,313 B2 · Method of prognosis associated with cases of postpartum hemorrhage > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,784,313 B2 - Document ID: US8784313B2 - Status: Granted - Kind: B2 - Application number: 13/057,633 - Filed: 2009-08-06 - Published: 2013-07-25 - Granted: 2014-07-22 - Earliest claimed: 2008-08-06 - Assignees: Assistance Publique-Hopitaux de Paris - Applicants: Alexandre Mebazaa; Etienne Gayat; Matthieu Resche-Rigon; Olivier Morel; Yann Fargeaudou; Matthias Rossignol; Didier Payen - Inventors: Alexandre Mebazaa; Etienne Gayat; Matthieu Resche-Rigon; Olivier Morel; Yann Fargeaudou; Matthias Rossignol; Didier Payen - Web page: https://patentgrep.com/patent/US8784313B2 ## CPC - A61B 5/4318: {Evaluation of the lower reproductive system (A61B5/4343 takes precedence)} - G01N 33/86: involving blood coagulating time {or factors, or their receptors} - G01N 2333/4712: Muscle proteins, e.g. myosin, actin, protein - G01N 2333/75: Fibrin; Fibrinogen - G01N 2800/224: Haemostasis or coagulation - G01N 2800/368: Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Novel prognosis methods associated with cases of postpartum haemorrhage providing a predictive test enabling practitioners to provide better management of patients suffering from postpartum haemorrhage. Different risk factors exist on which a score allowing prediction of the need to carry out invasive procedures to stop bleeding has been developed. ## Claims ### Claim 1 An in vitro prognosis method for halted bleeding in a patient suffering from postpartum haemorrhage without any invasive procedure, comprising the following steps: a) determining with an assay apparatus the plasmatic fibrinogen concentration, troponin I blood concentration and prothrombin time from a biological sample of said patient; b) examining at least two clinical markers of said patient chosen from the group consisting of heart rate and the presence of placentation anomalies; c) calculating a Z score as per the following formula: Z=a+b+c+d+e, i) where a is associated with the existence of placentation anomalies in said patient, with a having a value of 0 if no placental anomaly is observed in said patient, and a having a value of 1 if one or more placentation anomalies are observed in said patient; ii) where b is associated with the heart rate of said patient, with b having a value of 0 if the heart rate of said patient is less than or equal to 15 bpm (beats per minute) and b having a value of 1 if the heart rate is higher than 115 bpm; iii) where c is associated with the plasmatic fibrinogen concentration of said patient, with c having a value of 0 if said level is equal to or higher than 2 g/L and c having a value of 1 if said level is lower than 2 g/L; iv) where d is associated with the blood troponin I concentration of said patient, with d having a value of 0 when said concentration is lower than 0.02 ng/L, and d having a value of 1 if said concentration is higher than or equal to 0.02 ng/L; v) where e is associated with the prothombin time (PT) of said patient, e having a value of 0 if said prothrombin time is higher than or equal to 50%, and e having a value of 1 if said prothrombin time is less than 50%; wherein a Z score higher than or equal to a value of 2 is indicative of the need to carry out invasive procedure to stop bleeding in said patient suffering from postpartum haemorrhage. ### Claim 2 (depends on 1) The method according to claim 1, characterized in that said biological sample is a blood sample. ### Claim 3 (depends on 1) The method according to claim 1 , characterized in that troponin I is cardiac troponin I. ### Claim 4 (depends on 1) The method according to claim 1, characterized in that d has a value of 0 if the blood troponin I concentration is lower than 1 pg/L. ### Claim 5 (depends on 1) The method according to claim 1, characterized in that the placentation anomalies are chosen from the group consisting of placenta praevia, placenta accreta, placenta increta, and placenta percreta. ### Claim 6 (depends on 1) The method according to claim 1, characterized in that said invasive procedure is haemostatic surgery or uterine arterial embolisation. ### Claim 7 (depends on 6) The method according to claim 6, characterized in that said invasive procedure is haemostatic surgery chosen from the group comprising hysterectomy, vessel ligature, and intra-abdominal packing. ### Claim 8 (depends on 1) The method according to claim 1, characterized in that d has a value of 0 if the blood troponin I concentration is lower than 10 pg/L.