# US 8,783,151 B1 · Methods of manufacturing vascular treatment devices

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- Number: US 8,783,151 B1
- Document ID: US8783151B1
- Status: Granted
- Kind: B1
- Application number: 14/012,348
- Filed: 2013-08-28
- Granted: 2014-07-22
- Earliest claimed: 2013-03-15
- Assignees: Insera Therapeutics, Inc.
- Applicants: Insera Therapeutics, Inc.
- Inventors: Vallabh Janardhan; Vikram Janardhan
- Web page: https://patentgrep.com/patent/US8783151B1

## CPC

- A61B 17/221: Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)}
- A61B 17/12109: {in a blood vessel}
- A61B 17/12113: {within an aneurysm}
- A61B 17/12118: {for positioning in conjunction with a stent}
- A61B 17/12122: {within the heart (for closing a cardiac septal defect A61B17/0057)}
- A61B 17/12172: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61B 17/22031: {Gripping instruments, e.g. forceps, for removing or smashing calculi (A61B17/221 takes precedence)}
- A61M 25/0015: {Making lateral openings in a catheter tube, e.g. holes, slits, ports, piercings of guidewire ports; Methods for processing the holes, e.g. smoothing the edges}
- A61M 25/0021: {characterised by the form of the tubing (A61M25/0054 takes precedence)}
- A61M 25/0043: {characterised by structural features}
- D04C 1/06: Braid or lace serving particular purposes
- D04C 3/48: Auxiliary devices
- A61B 2017/00526: {Methods of manufacturing}
- A61B 2017/00867: {shape memory effect}
- A61B 2017/00955: {thermoplastic}
- A61B 2017/12077: {Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory}
- A61B 2017/22034: {for gripping the obstruction or the tissue part from inside}
- A61B 2017/22038: {with a guide wire}
- A61B 2017/2217: {single wire changing shape to a gripping configuration}
- A61B 2090/3966: {Radiopaque markers visible in an X-ray image}
- A61M 2025/0042: {Microcatheters, cannula or the like having outside diameters around 1 mm or less}
- D10B 2509/06: Vascular grafts; stents
- Y10T 83/0596: Cutting wall of hollow work
- Y10T 156/1062: Prior to assembly
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- D04C: BRAIDING OR MANUFACTURE OF LACE, INCLUDING BOBBIN-NET OR CARBONISED LACE; BRAIDING MACHINES; BRAID; LACE (machines for making soles from strips of material A43D29/00; cane working B27J1/00)
- D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

## Claims

### Claim 1

A method of manufacturing a vascular treatment device, the method comprising:
arranging a plurality of spools on a yarn wheel, at least some of the spools comprising radiopaque wires and at least some of the spools comprising shape memory wires;
braiding the radiopaque wires and the shape memory wires in a one-over-one-under-one pattern around a first mandrel to form a textile structure;
shape setting the textile structure in a substantially cylindrical shape;
providing a second mandrel comprising bulbs and necks, wherein the second mandrel comprises the bulbs threaded along a strand;
securing the shape-set textile structure on the second mandrel, wherein securing the shape-set textile structure on the second mandrel comprises wrapping at least one of bangles and c-shaped clamps around the necks of the second mandrel;
shape setting the shape-set textile structure on the second mandrel; and
removing the shape-set textile structure from the second mandrel.

### Claim 2 (depends on 1)

The method of claim 1, wherein securing the shape-set textile structure on the second mandrel comprises wrapping wire around the necks of the second mandrel.

### Claim 3 (depends on 1)

The method of claim 1, wherein the radiopaque wires comprise platinum tungsten wires.

### Claim 4 (depends on 1)

The method of claim 1, wherein the shape memory wires comprise nickel titanium wires.

### Claim 5 (depends on 1)

The method of claim 1, further comprising bonding the shape-set textile structure to a delivery system.

### Claim 6 (depends on 5)

The method of claim 5, wherein bonding the shape-set textile structure to the delivery system comprises inlay bonding.

### Claim 7 (depends on 6)

The method of claim 6, further comprising, before bonding the shape-set textile structure to the delivery system, positioning the wires in a pinch ring or a pinch cylinder.

### Claim 8 (depends on 5)

The method of claim 5, wherein bonding the shape-set textile structure to the delivery system comprises overlay bonding.

### Claim 9 (depends on 8)

The method of claim 8, wherein bonding the shape-set textile structure to the delivery system comprises bonding a proximal end of the shape-set textile structure to a distal end of the delivery system.

### Claim 10 (depends on 8)

The method of claim 8, wherein bonding the shape-set textile structure to the delivery system comprises bonding a distal end of the shape-set textile structure to a distal end of the delivery system.

### Claim 11 (depends on 8)

The method of claim 8, wherein bonding the shape-set textile structure to the delivery system comprises placing a tubing around a bonding area.

### Claim 12 (depends on 5)

The method of claim 5, wherein bonding the shape-set textile structure to the delivery system comprises soldering the shape-set textile structure to the cut hypotube delivery system.

### Claim 13 (depends on 5)

The method of claim 5, wherein the delivery system comprises a cut hypotube.

### Claim 14 (depends on 5)

The method of claim 5, wherein the delivery system comprises a hypotube comprising a first pattern and a second pattern.

### Claim 15 (depends on 14)

The method of claim 14, further comprising:
cutting the first pattern of longitudinally-spaced rows each comprising two kerfs and two stems into the hypotube, the two stems in each of the rows of the first pattern circumferentially opposite, the stems of the first pattern offset in a first circumferential direction; and
cutting the second pattern of longitudinally-spaced rows each comprising two kerfs and two stems into the hypotube, the two stems in each of the rows of the second pattern circumferentially opposite, the stems of the second pattern offset in a second circumferential direction opposite the first circumferential direction, the second pattern singly alternatingly interspersed with the first pattern.

### Claim 16 (depends on 15)

The method of claim 15, wherein cutting the first pattern and cutting the second pattern comprises cutting rounded edges of the kerfs in each of the rows of the first pattern and the second pattern.

### Claim 17 (depends on 15)

The method of claim 15, wherein cutting the first pattern and cutting the second pattern comprises cutting each of the rows of the first pattern and the second pattern at an angle with respect to a longitudinal axis of the hypotube.

### Claim 18 (depends on 15)

The method of claim 15, wherein the hypotube comprises stainless steel.

### Claim 19 (depends on 15)

The method of claim 15, wherein the hypotube comprises nitinol.

### Claim 20 (depends on 15)

The method of claim 15, wherein a pitch of the longitudinally-spaced rows of the first pattern and the second pattern varies longitudinally along the hypotube.