# US 8,783,121 B2 · Liquid collecting system and a method therefor > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,783,121 B2 - Document ID: US8783121B2 - Status: Granted - Kind: B2 - Application number: 13/256,221 - Filed: 2009-03-19 - Published: 2012-01-05 - Granted: 2014-07-22 - Earliest claimed: 2009-03-19 - Assignees: Shumadzu Corporation; National Institute of Radiological Sciences - Applicants: Nobuya Hashizume; Keishi Kitamura; Takahiro Nishimoto; Yuichi Kimura; Chie Seki; Iwao Kanno - Inventors: Nobuya Hashizume; Keishi Kitamura; Takahiro Nishimoto; Yuichi Kimura; Chie Seki; Iwao Kanno - Web page: https://patentgrep.com/patent/US8783121B2 ## CPC - G01N 35/1097: {characterised by the valves (valves in general F16K)} - A61B 5/02042: {Determining blood loss or bleeding, e.g. during a surgical procedure} - A61B 5/15003: {for venous or arterial blood} - A61B 5/150755: {Blood sample preparation for further analysis, e.g. by separating blood components or by mixing} - A61B 5/150992: {Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; Blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings or valves} - A61B 5/155: {Devices} specially adapted for continuous or multiple sampling, e.g. at predetermined intervals {(devices loaded with multiple lancets simultaneously A61B5/15146)} - G01N 35/1004: {Cleaning sample transfer devices} - A61B 5/150213: {Venting means} - A61B 5/150221: {Valves} - A61B 5/150229: {Pumps for assisting the blood sampling} - A61B 5/150946: {Means for varying, regulating, indicating or limiting the speed or time of blood collection} - A61B 5/157: {Devices} characterised by integrated means for measuring characteristics of blood - G01N 2035/00237: {Handling microquantities of analyte, e.g. microvalves, capillary networks} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A blood collecting apparatus includes a cleaning solution piping. The cleaning solution piping feeds into a flow path a heparin solution which is a liquid other than blood to be measured, in order to return the blood present in the flow path to a catheter disposed upstream of a blood inlet of the flow path. Thus, the blood having flowed into the flow path in an amount more than is necessary for blood collection, which corresponds to a portion returned to the upstream catheter of the blood to be measured present in the flow path, can be used in a next blood collection. As a result, the amount of collected blood can be reduced. The liquid to be measured is separated apart by means of a gas, and the flow path is cleaned in a way to leave no impurities in the flow path, thereby preventing impurities from mixing into the liquid to be measured. ## Claims ### Claim 1 A liquid collecting system having a liquid collecting apparatus for collecting a liquid to be measured, as separated in a time series, comprising (a) a flow path through which the liquid to be measured flows, (b) an extracting device provided in an intermediate position of the flow path to insert a gas or a liquid other than the liquid to be measured, as separators, at designated predetermined intervals, thereby to take out the liquid to be measured, as separated in the time series, and a dripping device for successively dripping the taken-out liquid to be measured, a liquid storage device having a plurality of grooved flow paths for storing the dripping liquid individually, and a control device for performing positional control, as interlocked to the dripping, to locate the grooved flow paths successively in a dripping position; the liquid collecting system further comprising (e) an optical measuring device for measuring length information on the liquid while optically monitoring the liquid to be measured or other liquid flowing through the flow path; wherein a volume of the liquid to be measured which is to be taken out by the extracting device is controlled by controlling intervals of the separators based on a result of measurement by the optical measuring device. ### Claim 2 (depends on 1) The liquid collecting system according to claim 1, comprising (d) a gas feeding device for feeding a gas into the flow path in order to remove the liquid to be measured or a different liquid remaining in the flow path. ### Claim 3 (depends on 2) The liquid collecting system according to claim 2, wherein, when the separators are the gas, the extracting device and the gas feeding device are combined into one. ### Claim 4 (depends on 1) The liquid collecting system according to claim 1, wherein the flow path is formed by grooving planar substrates in a predetermined size. ### Claim 5 (depends on 4) The liquid collecting system according to claim 4, wherein the flow path is formed of a flow path into which the liquid to be measured is fed, and a single or a plurality of flow paths for feeding the liquid other than the liquid to be measured or the gas. ### Claim 6 (depends on 1) The liquid collecting system according to claim 1, wherein the liquid to be measured is blood, and the liquid collecting apparatus is an apparatus for collecting blood. ### Claim 7 (depends on 1) The liquid collecting system according to claim 1, wherein the liquid other than the liquid to be measured for a predetermined time and remaining in the flow path is discharged by filling the flow path with the liquid other than the liquid to be measured, and feeding the gas into the flow path to clean the flow path. ### Claim 8 (depends on 7) The liquid collecting system according to claim 7, wherein the liquid to be measured for the predetermined time is prevented from mixing with the other liquid, by feeding the gas into the flow path to remove the liquid remaining therein. ### Claim 9 (depends on 1) The liquid collecting system according to claim 1, wherein the liquid to be measured is a liquid including a fluorescent agent, and the liquid collecting apparatus is an apparatus for collecting the liquid. ### Claim 10 A liquid collecting system having a liquid collecting apparatus for collecting a liquid to be measured, as separated in a time series, comprising (a) a flow path through which the liquid to be measured flows, (b) an extracting device provided in an intermediate position of the flow path to insert a gas or a liquid other than the liquid to be measured, as separators, at designated predetermined intervals, thereby to take out the liquid to be measured, as separated in the time series, and a dripping device for successively dripping the taken-out liquid to be measured, a liquid storage device having a plurality of grooved flow paths for storing the dripping liquid individually, and a control device for performing positional control, as interlocked to the dripping, to locate the grooved flow paths successively in a dripping position; the liquid collecting system further comprising (e) an optical measuring device for measuring length information on the liquid while optically monitoring the liquid to be measured or other liquid flowing through the flow path; wherein a volume of the liquid to be fed is controlled based on the result of measurement by the optical measuring device. ### Claim 11 A liquid collecting method for collecting a liquid to be measured, as separated in a time series, by inserting a gas or a liquid other than the liquid to be measured, as separators at designated predetermined intervals in the liquid to be measured, wherein the liquid to be measured, which is taken out as separated in a time series by insertion of the separators, is successively dripped, and positional control is performed for a liquid storage device having a plurality of grooved flow paths for storing the dripping liquid individually, such that, as interlocked to the dripping, the grooved flow paths are successively located in a dripping position; the liquid collecting method further comprising measuring length information on the liquid with an optical measuring device while optically monitoring the liquid to be measured or other liquid flowing through the flow path; wherein a volume of the liquid to be measured which is to be taken out by the extracting device is controlled by controlling intervals of the separators based on a result of measurement by the optical measuring device. ### Claim 12 (depends on 11) The liquid collecting method according to claim 11, wherein, when feeding the liquid other than the liquid to be measured into the flow path, the flow path extending from a liquid inlet to a liquid outlet is filled with the other liquid. ### Claim 13 (depends on 12) The liquid collecting method according to claim 12, wherein, when collecting the liquid to be measured, what is fed into the flow path is the liquid to be measured after the other, filling liquid is removed. ### Claim 14 (depends on 12) The liquid collecting method according to claim 12, wherein, when filling the flow path extending from the liquid inlet to the liquid outlet with the liquid other than the liquid to be measured, also the portion upstream of the liquid inlet is filled with the other liquid. ### Claim 15 (depends on 11) The liquid collecting method according to claim 11, wherein a gas is fed into the flow path in order to remove the liquid to be measured or other liquid remaining in the flow path. ### Claim 16 (depends on 11) The liquid collecting method according to claim 11, wherein, when the liquid other than the liquid to be measured remains in or fills the portion upstream of the liquid inlet, the other liquid remaining in or filling the upstream portion is fed into the flow path while collecting the liquid to be measured with the upstream portion, and the liquid inlet is closed when a boundary between the liquid to be measured and the other liquid is fed as far as the liquid inlet. ### Claim 17 (depends on 11) The liquid collecting method according to claim 11, wherein the flow path is filled with the liquid other than the liquid to be measured, and the flow path is cleaned by feeding gas into the flow path, thereby discharging the liquid other than the liquid to be measured which remains in the flow path. ### Claim 18 (depends on 17) The liquid collecting method according to claim 17, wherein, by feeding the gas into the flow path to discharge the liquid remaining therein, the liquid to be measured for the predetermined time is prevented from mixing with the other liquid. ### Claim 19 (depends on 11) The liquid collecting method according to claim 11, wherein the liquid to be measured is blood, and the liquid collecting method is a method for collecting blood. ### Claim 20 (depends on 11) The liquid collecting method according to claim 11, wherein the liquid to be measured is a liquid including a fluorescent agent, and the liquid collecting method is a method for collecting the liquid. ### Claim 21 A liquid collecting method for collecting a liquid to be measured, as separated in a time series, by inserting a gas or a liquid other than the liquid to be measured, as separators at designated predetermined intervals in the liquid to be measured, wherein the liquid to be measured, which is taken out as separated in a time series by insertion of the separators, is successively dripped, and positional control is performed for a liquid storage device having a plurality of grooved flow paths for storing the dripping liquid individually, such that, as interlocked to the dripping, the grooved flow paths are successively located in a dripping position; the liquid collecting method further comprising measuring length information on the liquid with an optical measuring device while optically monitoring the liquid to be measured or other liquid flowing through the flow path; wherein a volume of the liquid to be fed is controlled based on the result of measurement by the optical measuring device.