Targeted binding agents against B7-H1
AssigneeMedImmune, LLC
InventorsChristophe Queva, Michelle Morrow, Scott Hammond, Marat Alimzhanov, John Babcook, Ian Nevin Foltz, Jaspal Singh Kang, Laura Sekirov, Melanie Boyle, Matthieu Chodorge, Ross A. Stewart, Kathleen Ann Mulgrew
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Abstract
Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.
Claims31
An antibody or fragment thereof wherein the antibody binds to the same epitope on the extracellular domain of human B7-H1 as any one of an antibody comprising:
- (a) a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.7A4_G which was deposited at the National Collections of Industrial and Marine Bacteria (NCIMB) under deposit number 41598 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.7A4_G which was deposited at the NCIMB under deposit number 41598;
- or
- (b) a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.14H9_G which was deposited at the NCIMB under deposit number 41597 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.14H9_G which was deposited at the NCIMB under deposit number 41597;
- or
- (c) a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.9D10_NG which was deposited at the NCIMB under deposit number 41599 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.9D10_NG which was deposited at the NCIMB under deposit number 41599.
An antibody or fragment thereof having an amino acid sequence comprising:
- a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.7A4_G which was deposited at the National Collections of Industrial and Marine Bacteria (NCIMB) under deposit number 41598 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.7A4_G which was deposited at the NCIMB under deposit number 41598;
- or
- a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.14H9_G which was deposited at the NCIMB under deposit number 41597 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.14H9_G which was deposited at the NCIMB under deposit number 41597;
- or
- a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.9D10_NG which was deposited at the NCIMB under deposit number 41599 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.9D10_NG which was deposited at the NCIMB under deposit number 41599.
A purified antibody or antibody fragment, wherein the antibody or the fragment immunospecifically binds B7-H1 and comprises a heavy chain variable domain having at least 90% identity to the amino acid of SEQ ID NO:72 and comprises a light chain variable domain having at least 90% identity to the amino acid sequence of SEQ ID NO:77, wherein said antibody has the activity of binding to B7-H1.
Dependencies are inferred from the claim text.