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US 8,778,991 B2Granted
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
AssigneeXenoPort, Inc.
InventorsArchana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A. Virsik
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Abstract
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.
Claims9
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- R6 is chosen from C1-6 alkyl, substituted C1-6 alkyl, C1-6 heteroalkyl, C3-8 cycloalkyl, substituted C3-8 cycloalkyl, C6-8 aryl, substituted C6-8 aryl, and —OR10 wherein R10 is chosen from C1-6 alkyl, substituted C1-6 alkyl, C3-10 cycloalkyl, substituted C3-10 cycloalkyl, C6-10 aryl, and substituted C6-10 aryl;
- R7 and R8 are independently chosen from hydrogen, C1-6 alkyl, and substituted C1-6 alkyl;
- and
- R9 is methyl;
- wherein each substituent group is independently chosen from, —OH, —CN, —CF3, ═O, —NO2, benzyl, —C(O)NR112, —R11, —OR11, —C(O)R11, —COOR11, and —NR112 wherein each R11 is independently chosen from hydrogen and C1-4 alkyl.
3 more elements
Dependencies are inferred from the claim text.