# US 8,772,672 B2 · Hybrid stent and method of making

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- Number: US 8,772,672 B2
- Document ID: US8772672B2
- Status: Granted
- Kind: B2
- Application number: 13/543,422
- Filed: 2012-07-06
- Published: 2012-11-01
- Granted: 2014-07-08
- Earliest claimed: 2002-04-01
- Assignees: Abbott Cardiovascular Systems Inc.
- Applicants: Santosh Prabhu
- Inventors: Santosh Prabhu
- Web page: https://patentgrep.com/patent/US8772672B2

## CPC

- A61L 31/048: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence)}
- A61F 2/04: Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95)
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/89: the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F 2/915: with bands having a meander structure, adjacent bands being connected to each other
- A61K 31/727: Heparin; Heparan
- A61L 31/022: {Metals or alloys}
- A61L 31/10: Macromolecular materials
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61L 31/18: Materials at least partially X-ray or laser opaque
- B23K 26/38: by boring or cutting
- B23K 26/402: involving non-metallic material, e.g. isolators
- B29C 41/08: Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder {(spray-up of reinforcing fibres B29C70/305)}
- B29C 41/14: Dipping a core {(B29C41/10 takes precedence)}
- B29C 41/20: incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
- B29C 41/22: Making multilayered or multicoloured articles
- B29C 65/16: Laser beams
- B29C 65/68: using auxiliary shrinkable elements
- A61F 2/07: Stent-grafts
- A61F 2/852: Two or more distinct overlapping stents
- A61F 2002/072: {Encapsulated stents, e.g. wire or whole stent embedded in lining}
- A61F 2002/91558: {connected peak to peak}
- A61F 2210/0076: multilayered, e.g. laminated structures
- A61F 2230/0013: Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
- A61F 2230/0054: V-shaped
- A61F 2230/0069: cylindrical
- A61F 2240/001: Designing or manufacturing processes
- A61F 2250/0032: differing in radiographic density
- A61F 2250/0063: Nested prosthetic parts
- A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body
- A61L 2300/236: Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
- A61L 2300/606: Coatings
- B23K 2103/42: {Plastics other than composite materials}
- B23K 2103/50: {Inorganic materials other than metals or composite materials}
- B23K 2103/54: {Glass}
- B29K 2027/18: PTFE, i.e. polytetrafluoroethylene {, e.g. ePTFE, i.e. expanded polytetrafluoroethylene}
- B29L 2031/7534: {Cardiovascular protheses}
- Y10T 29/49906: Metal deforming with nonmetallic bonding
- Y10T 428/139: Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T 428/1393: Multilayer [continuous layer]
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B23K: SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- B29K: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR {MOULDS, } REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A stent is formed by encasing or encapsulating metallic rings in an inner polymeric layer and an outer polymeric layer. At least one polymer link connects adjacent metallic rings. The stent is drug loaded with one or more therapeutic agent or drug, for example, to reduce the likelihood of the development of restenosis in the coronary arteries. The inner and outer polymeric materials can be of the same polymer or different polymer to achieve different results, such as enhancing flexibility and providing a stent that is visible under MRI, computer tomography and x-ray fluoroscopy.

## Claims

### Claim 1

A method of making a hybrid stent, comprising:
coating a mandrel with a first polymer to form a first polymeric tube;
mounting a plurality of unconnected metallic rings over the first polymeric tube;
applying a second polymeric material over the metallic rings and the first polymeric tube to form the stent;
selectively removing portions of the first polymeric tube and second polymeric tube to form polymeric links which connect adjacent metallic rings together; and
removing the stent from the mandrel.

### Claim 2 (depends on 1)

The method of claim 1, wherein the first polymeric tube is formed by dip-coating the mandrel in a first polymeric material.

### Claim 3 (depends on 1)

The method of claim 1, wherein the second polymeric material is applied to the rings and the first polymeric tube by dip-coating.

### Claim 4 (depends on 1)

The method of claim 1, wherein the second polymeric material is sprayed onto the metallic rings and the first polymeric tube.

### Claim 5 (depends on 1)

The method of claim 1, wherein the links for connecting adjacent metallic rings are formed by laser ablation of the first and second polymeric materials.

### Claim 6 (depends on 1)

The method of claim 1, wherein a therapeutic drug is loaded into either or both of the first and second polymeric materials.