# US 8,772,540 B2 · Thermal responsive molecule

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- Number: US 8,772,540 B2
- Document ID: US8772540B2
- Status: Granted
- Kind: B2
- Application number: 12/950,098
- Filed: 2010-11-19
- Published: 2011-05-26
- Granted: 2014-07-08
- Earliest claimed: 2009-11-19
- Assignees: Kyushu University, National University Corporation
- Applicants: Noboru Koga; Satoru Karasawa; Hiroyuki Hayashi
- Inventors: Noboru Koga; Satoru Karasawa; Hiroyuki Hayashi
- Web page: https://patentgrep.com/patent/US8772540B2

## CPC

- C07C 275/40: being further substituted by nitrogen atoms not being part of nitro or nitroso groups
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Provided is a thermal responsive molecule favorable as a thermal responsive low-molecular hydrogelling agent or the like that gels in response to heat. The thermal responsive molecule is characterized in that an amphiphilic side chain obtained by bonding a hydrophilic side chain such as triethylene glycol and a hydrophobic group such as an octyl group is introduced into a C3-symmetric disc-shaped molecular skeleton such as 1,3,5-benzenetriyltriurea. For example, the thermal responsive molecule is 1,1′,1″-(benzene-1,3,5-triyl)tris{3-(2,5,8,11-tetraoxaheptadecan-17-yl)urea} or the like.

## Claims

### Claim 1

A thermal responsive molecule of general formula (1), in which an amphiphilic side chain obtained by bonding a hydrophilic side chain and a hydrophobic group is introduced into a C3-symmetric disc-shaped molecular skeleton:
EgnCmU (1)
wherein Eg represents ethylene glycol; n indicates an integer of from 3 to 10; C represents an aliphatic hydrocarbon group; m indicates an integer of from 2 to 15; and U represents an urea skeleton.

### Claim 2 (depends on 1)

The thermal responsive molecule according to claim 1, wherein U is 1,3,5-benzenetriyltriurea or 1,3,5-benzenetriyltriamide.

### Claim 3 (depends on 1)

The thermal responsive molecule according to claim 1, wherein n is 3, m is 8, and U is 1,3,5-benzenetriyltriurea.

### Claim 4 (depends on 3)

The thermal responsive molecule according to claim 3, wherein the thermal responsive molecule is a low-molecular hydrogelling agent.