# US 8,772,463 B2 · Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof

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- Number: US 8,772,463 B2
- Document ID: US8772463B2
- Status: Granted
- Kind: B2
- Application number: 12/876,520
- Filed: 2010-09-07
- Published: 2011-03-10
- Granted: 2014-07-08
- Earliest claimed: 2007-03-26
- Assignees: Snu R&Db Foundation
- Applicants: Seung Bum Park; Hyang Yeon Lee; Jong Min Park
- Inventors: Seung Bum Park; Hyang Yeon Lee; Jong Min Park
- Web page: https://patentgrep.com/patent/US8772463B2

## CPC

- C07H 15/26: Acyclic or carbocyclic radicals, substituted by hetero rings
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)

## Abstract

Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases.

## Claims

### Claim 1

A fluorescent glucose analogue, represented by Formula 1 or Formula 2:
wherein
R1 is —(CH2)n-A-, wherein n is an integer of from 1 to 10, and A is piperazine;
R2 is —(CH2)4-Cy3; and
Y is O.

### Claim 2 (depends on 1)

The fluorescent glucose analogue according to claim 1, being represented by the following Chemical Formula 5

### Claim 3 (depends on 1)

A bioprobe, comprising the fluorescent glucose analogue of claim 1.