# US 8,772,350 B1 · Methods of treating gastrointestinal spasms in a subject having diverticulitis > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,772,350 B1 - Document ID: US8772350B1 - Status: Granted - Kind: B1 - Application number: 14/173,079 - Filed: 2014-02-05 - Published: 2014-06-26 - Granted: 2014-07-08 - Earliest claimed: 2012-12-23 - Assignees: LiveLeaf, Inc. - Applicants: LiveLeaf, Inc. - Inventors: Alexander L Huang; Gin Wu - Web page: https://patentgrep.com/patent/US8772350B1 ## CPC - A61K 33/40: Peroxides - A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} - A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)} - A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin - A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol} - A61K 31/7028: Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages - A61K 31/7034: attached to a carbocyclic compound, e.g. phloridzin - A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} - A61K 36/185: Magnoliopsida (dicotyledons) - A61K 36/22: Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak - A61K 36/3482: {Cannabis} - A61K 36/742: {Coffea, e.g. coffee} - A61K 36/82: Theaceae (Tea family), e.g. camellia - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system - A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea. ## Claims ### Claim 1 A method of treating a gastrointestinal spasm in a subject having diverticulitis, the method comprising: administering an effective amount of a composition to a subject having a gastrointestinal spasm, the composition having a water soluble polyphenol that was (i) water-extracted from a mixture of pomegranate husk and green tea leaf and (ii) combined with hydrogen peroxide prior to the administering; wherein, the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition; the polyphenol comprises a tannin; the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and, the composition relieves a gastrointestinal spasm in the subject having diverticulitis when compared to second subject in a control group also having diverticulitis in which the composition was not administered. ### Claim 2 (depends on 1) The method of claim 1, wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.5% based on total dry weight of the composition. ### Claim 3 (depends on 1) The method of claim 1, wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.0% based on total dry weight of the composition. ### Claim 4 (depends on 1) The method of claim 1, wherein the relief of the spasm is measured using a response selected from the group consisting of a reduction in abdominal pain, a reduction in bloating, a reduction in forceful defecation, a reduction in forceful vomiting, a reduction in defecation urgency, a reduction in constipation, and a reduction in incontinence. ### Claim 5 (depends on 1) The method of claim 1, wherein the polyphenol comprises a hydrolysable tannin. ### Claim 6 (depends on 1) The method of claim 1, wherein the polyphenol comprises a water soluble condensed tannin. ### Claim 7 (depends on 1) The method of claim 1, wherein the polyphenol comprises a combination of a hydrolysable tannin and a water soluble condensed tannin. ### Claim 8 (depends on 1) The method of claim 1, wherein the polyphenol comprises a flavanol. ### Claim 9 (depends on 1) The method of claim 1, wherein the polyphenol comprises a catechin. ### Claim 10 (depends on 1) The method of claim 1, wherein the polyphenol comprises gallic acid, epigallic acid, or a combination thereof. ### Claim 11 (depends on 1) The method of claim 1, wherein the composition is administered in combination with an oral rehydration solution. ### Claim 12 (depends on 1) The method of claim 1, wherein the polyphenol an ellagitannin and a gallotannin. ### Claim 13 (depends on 1) The method of claim 1, wherein the polyphenol includes a punicalagin. ### Claim 14 A method of treating a gastrointestinal spasm in a subject having diverticulitis, comprising: administering an effective amount of a composition to a subject having a gastrointestinal spasm, the composition produced from a process including extracting a water soluble polyphenol from a combination of green tea leaf and pomegranate husk; combining the polyphenol with hydrogen peroxide prior to the administering; wherein, the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; selecting a desired concentration for the composition; and, diluting the composition to the desired concentration for the administering; wherein, the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition; the polyphenol comprises a tannin; and, the composition relieves a gastrointestinal spasm in the subject having diverticulitis when compared to a second subject in a control group also having diverticulitis in which the composition was not administered. ### Claim 15 (depends on 14) The method of claim 14, wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.5% based on total dry weight of the composition. ### Claim 16 (depends on 14) The method of claim 14, wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.0% based on total dry weight of the composition. ### Claim 17 (depends on 14) The method of claim 14, wherein the relief of the spasm is measured using a response selected from the group consisting of a reduction in abdominal pain, a reduction in bloating, a reduction in forceful defecation, a reduction in forceful vomiting, a reduction in defecation urgency, a reduction in constipation, and a reduction in incontinence. ### Claim 18 (depends on 14) The method of claim 14, wherein the polyphenol comprises a hydrolysable tannin. ### Claim 19 (depends on 14) The method of claim 14, wherein the polyphenol comprises a water soluble condensed tannin. ### Claim 20 (depends on 14) The method of claim 14, wherein the polyphenol comprises a combination of a hydrolysable tannin and a water soluble condensed tannin. ### Claim 21 (depends on 14) The method of claim 14, wherein the polyphenol comprises a flavanol. ### Claim 22 (depends on 14) The method of claim 14, wherein the polyphenol comprises a catechin. ### Claim 23 (depends on 14) The method of claim 14, wherein the polyphenol comprises gallic acid, epigallic acid, or a combination thereof. ### Claim 24 (depends on 14) The method of claim 14, wherein the polyphenol includes an ellagitannin and a gallotannin. ### Claim 25 (depends on 14) The method of claim 14, wherein the polyphenol includes a punicalagin. ### Claim 26 A method of treating a gastrointestinal spasm in a subject suffering from diverticulitis, comprising: administering an effective amount of a composition to a subject having a gastrointestinal spasm, the composition produced from a process including obtaining a water extract from a green tea leaf and a water extract from a pomegranate husk; combining the water extract from the green tea leaf and the water extract from the pomegranate husk to form a mixture of polyphenols having a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and, adding hydrogen peroxide to the polyphenol prior to the administering, the hydrogen peroxide concentration selected from a group consisting of concentration ranges from about 0.001% to about 2.0%, from about 0.001% to about 1.5%, from about 0.001% to about 1.0%, and from about 0.001% to about 0.1%, each range based on total dry weight of the composition; wherein, the polyphenol comprises a tannin; and, the composition relieves a gastrointestinal spasm in the subject suffering from diverticulitis when compared to the baseline health of the subject prior to the administering.