# US 8,772,346 B2 · Pharmaceutical composition

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- Number: US 8,772,346 B2
- Document ID: US8772346B2
- Status: Granted
- Kind: B2
- Application number: 12/097,453
- Filed: 2006-11-09
- Published: 2009-12-03
- Granted: 2014-07-08
- Earliest claimed: 2005-11-09
- Assignees: Torrent Pharmaceuticals Limited
- Applicants: Samanta Gour; Nanda Nagesh
- Inventors: Samanta Gour; Nanda Nagesh
- Web page: https://patentgrep.com/patent/US8772346B2

## CPC

- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 9/2866: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 9/4858: {Organic compounds}
- A61K 9/4875: {Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/4858)}
- A61K 9/5084: {Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs (tablets containing such a mixture A61K9/2077)}
- A61K 31/04: Nitro compounds
- A61K 31/12: Ketones
- A61K 31/277: having a ring, e.g. verapamil
- A61K 9/2009: {Inorganic compounds}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to a pharmaceutical composition of practically water insoluble or low water soluble compounds containing catechol moiety by enhancing the solubility of such compounds using one or more alkalizing agent and optionally adding one or more pharmaceutically acceptable excipient. The present invention also relates to a process for preparing such pharmaceutical composition.

## Claims

### Claim 1

A pharmaceutical composition comprising entacapone or nitecapone and one or more alkalizing agent optionally with other active ingredient, without incorporating crosslinked cellulose derivative, which is croscarmellose sodium.

### Claim 2 (depends on 1)

A pharmaceutical composition according to claim 1, wherein said other active ingredient is carbidopa and/or levodopa.

### Claim 3 (depends on 1)

A pharmaceutical composition according to claim 1, wherein said alkalizing agent is selected from the group of sodium hydroxide, potassium hydroxide, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, potassium hydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate.