# US 8,772,341 B2 · Compositions for the treatment of hoof diseases

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- Number: US 8,772,341 B2
- Document ID: US8772341B2
- Status: Granted
- Kind: B2
- Application number: 12/440,405
- Filed: 2007-09-10
- Published: 2010-11-11
- Granted: 2014-07-08
- Earliest claimed: 2006-09-08
- Assignees: DeLaval Holding AB
- Applicants: Chris Foret; Alex Skender; Thomas C. Hemling
- Inventors: Chris Foret; Alex Skender; Thomas C. Hemling
- Web page: https://patentgrep.com/patent/US8772341B2

## CPC

- A61K 31/60: Salicylic acid; Derivatives thereof
- A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A61K 9/0017: {Non-human animal skin, e.g. pour-on, spot-on}
- A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)}
- A61K 31/095: Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/191: having two or more hydroxy groups, e.g. gluconic acid
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 31/201: having one or two double bonds, e.g. oleic, linoleic acids
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 47/08: containing oxygen, {e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Germicidal compositions containing one or more N,N-bis(3-aminopropyl) C6-C18 alkyl amines, such as N,N-bis(3-aminopropyl)dodecylamine, and methods of using the compositions for treatment or prevention of infectious hoof diseases are disclosed. The germicidal compositions remain active in the presence of manure, which eliminates the need to pre-clean the hooves before use, and have particular utility for treating or preventing papillomatous digital dermatitis, interdigital phlegmon, interdigital dermatitis, laminitis, white line disease, heel erosion and other hoof diseases.

## Claims

### Claim 1

A method for treating an infectious hoof disease of an animal, comprising:
topically administering a therapeutically effective amount of an aqueous composition comprising an N,N-bis(3-aminopropyl) C6-C18 alkyl amine to one or more hooves of an animal,
wherein the step of administering occurs without pre-treatment or pre-cleaning of the hoof or hooves.

### Claim 2 (depends on 1)

The method of claim 1, wherein the concentration of the N,N-bis(3-aminopropyl) C6-C18 alkyl amine ranges from 0.03% to 90% by weight.

### Claim 3 (depends on 1)

The method of claim 1, wherein the concentration of the N,N-bis(3-aminopropyl) C6-C18 alkyl amine ranges from 0.03% to 2% by weight.

### Claim 4 (depends on 1)

The method of claim 1, wherein the concentration of the N,N-bis(3-aminopropyl) C6-C18 alkyl amine ranges from 0.1% to 1% by weight.

### Claim 5 (depends on 1)

The method of claim 1, wherein the N,N-bis(3-aminopropyl) C6-C18 alkyl amine comprises N,N-bis(3-aminopropyl)dodecylamine.

### Claim 6 (depends on 1)

The method of claim 1, wherein the infectious hoof disease is selected from papillomatous digital dermatitis, interdigital phlegmon, interdigital dermatitis, laminitis, white line disease and heel erosion.

### Claim 7 (depends on 1)

The method of claim 1, wherein the aqueous composition further comprises a germicide selected from the group consisting of bronopol, chlorhexidine salts, C6-C12 fatty acids, triclosan, glycolic acid, lactic acid, polyhexamethyl biguanide, polyhexamethylene guanidine hydrochloride, polyhexamethylene guanidine hydrophosphate, poly[2-(2-ethoxy)-ethoxyethyl]-guanidinium chloride, benzyl alcohol, benzoic acid and mixtures thereof.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition is administered as one of a spray, a foam, a gel, an ointment, a cream, a footbath or a footwrap.