# US 8,772,339 B2 · Ethylgallate and related compounds as a treatment for sepsis and septic shock

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- Number: US 8,772,339 B2
- Document ID: US8772339B2
- Status: Granted
- Kind: B2
- Application number: 13/387,050
- Filed: 2010-02-24
- Published: 2012-11-01
- Granted: 2014-07-08
- Earliest claimed: 2009-02-24
- Applicants: Steven N. Mink; Hans Jacobs
- Inventors: Steven N. Mink; Hans Jacobs
- Web page: https://patentgrep.com/patent/US8772339B2

## CPC

- A61K 31/235: having an aromatic ring attached to a carboxyl group
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The use of ethyl gallate methyl gallate or 3,4-dihydroxybenzoate for treatment of septic shock Said compounds may also prophylactically treat septic shock via administration to a subject before the development of a fall in blood pressure.

## Claims

### Claim 1

A method of treating septic shock comprising administering to an individual in need of such treatment an effective amount of ethyl gallate, methyl gallate, or ethyl 3,4 dihydroxybenzoate.

### Claim 2 (depends on 1)

The method according to claim 1 wherein the effective amount is an amount ethyl gallate, methyl gallate or ethyl 3,4 dihydroxybenzoate sufficient to produce a serum range between 9.7×10-7 mol/L to 4.3×10-6 mol/L in the individual in need of such treatment.

### Claim 3

A method of prophylactically treating septic shock comprising administering to an individual in need of such treatment an effective amount of ethyl gallate, methyl gallate, or ethyl 3,4 dihydroxybenzoate.

### Claim 4 (depends on 3)

The method according to claim 3 wherein the effective amount is an amount ethyl gallate, methyl gallate or ethyl 3,4 dihydroxybenzoate sufficient to produce a serum range between 9.7×10-7 mol/L to 4.3×10-6 mol/L in the individual in need of such treatment.