# US 8,772,335 B2 · Adamantyl derivatives as therapeutic agents

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- Number: US 8,772,335 B2
- Document ID: US8772335B2
- Status: Granted
- Kind: B2
- Application number: 13/706,958
- Filed: 2012-12-06
- Published: 2013-06-06
- Granted: 2014-07-08
- Earliest claimed: 2011-12-06
- Assignees: Woman & Infants' Hospital of Rhode Island
- Applicants: Women & Infants' Hospital of Rhode Island
- Inventors: Richard G. Moore; Rakesh K. Singh
- Web page: https://patentgrep.com/patent/US8772335B2

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/26: Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
- A61K 31/27: of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- C07C 331/20: of a saturated carbon skeleton
- C07C 333/20: having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C 2603/74: Adamantanes
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.

## Claims

### Claim 1

A method for treating ovarian cancer or endometrial cancer in a subject in need of such treatment, the method comprising administering to said subject a therapeutically effective amount of a compound, wherein the compound comprises:
or a pharmaceutically acceptable salt, prodrug, tautomer, regioisomer, stereoisomer, diastereomer, enantiomer or racemate thereof.

### Claim 2 (depends on 1)

The method of claim 1, further comprising administering to said subject an inhibitor of epidermal growth factor (EGF).