# US 8,772,334 B2 · Synergistic antimicrobial mixtures > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,772,334 B2 - Document ID: US8772334B2 - Status: Granted - Kind: B2 - Application number: 13/135,958 - Filed: 2011-07-18 - Published: 2011-11-17 - Granted: 2014-07-08 - Earliest claimed: 2008-07-02 - Applicants: Kamlesh Gaglani; Maihua Yang - Inventors: Kamlesh Gaglani; Maihua Yang - Web page: https://patentgrep.com/patent/US8772334B2 ## CPC - C09D 5/14: Paints containing biocides, e.g. fungicides, insecticides or pesticides (C09D5/16 takes precedence) - A01N 47/18: containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring - A01N 59/14: Boron; Compounds thereof - A01N 59/16: Heavy metals; Compounds thereof - C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS ## Abstract A broad spectrum antimicrobial composition consisting essentially of an iodopropynyl compound in combination with a benzimidazole and a metal borate is disclosed. The composition can be used to protect industrial systems against microbial growth and, more particularly, to protect substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, wood-plastic composites, caulking, sealants, textiles, leather, wood, preservatives, metal working fluids, drilling muds, clay slurries, glazes, optical brighteners, carpet backing, and pigments against microbial growth. The composition can be used as a preservative for aqueous products. ## Claims ### Claim 1 An antifungal composition, consisting of: 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate in proportions effective for three-component synergy and optionally a solid or liquid vehicle; in which composition the proportion of zinc borate is less than 67 mass %, based on the total mass of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate. ### Claim 2 (depends on 1) The composition of claim 1, in which 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate are present in proportions effective for three-component synergy against Aspergillus niger. ### Claim 3 (depends on 1) The composition of claim 1, which is free of amine oxide and aliphatic amine. ### Claim 4 (depends on 1) The composition of claim 1, in which the proportions of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate (based on the total mass of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate) in a triangular coordinate graph are within the interior of a triangle having as vertices 0 mass % 3-iodo-2-propynyl butyl carbamate, 72 mass % 2-(methoxycarbonylamino)benzimidazole, and 28 mass % zinc borate; 100 mass % 3-iodo-2-propynyl butyl carbamate, 0 mass % 2-(methoxycarbonylamino)benzimidazole, and 0 mass % zinc borate; and 47 mass % 3-iodo-2-propynyl butyl carbamate, 0 mass % 2-(methoxycarbonylamino)benzimidazole, and 53 mass % zinc borate. ### Claim 5 (depends on 2) The composition of claim 2, which has a minimum inhibitory concentration against Aspergillus niger of about 4 ppm or less. ### Claim 6 (depends on 5) The composition of claim 5, which has a minimum inhibitory concentration against Aspergillus niger of about 1 ppm or less. ### Claim 7 (depends on 1) The composition of claim 1, in which 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate are present in proportions effective for three-component synergy against Aureobasidium pullulans. ### Claim 8 (depends on 7) The composition of claim 7, which has a minimum inhibitory concentration against Aureobasidium pullulans of about 2 ppm or less. ### Claim 9 (depends on 1) The composition of claim 1, in which 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate are present in proportions effective for three-component synergy against Penicillium sp. ### Claim 10 (depends on 9) The composition of claim 9, which has a minimum inhibitory concentration against Penicillium sp. of about 0.5 ppm or less. ### Claim 11 A method for making a polymeric material that is resistant to fungal infestation, which method consists of: introducing into the polymeric material an antifungal composition consisting of 3-iodo-2-propynyl-N-n-butylcarbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate in proportions effective for three-component synergy and optionally a solid or liquid vehicle; in which method the proportion of zinc borate is less than 67 mass %, based on the total mass of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate. ### Claim 12 (depends on 11) The method of claim 11, in which the antifungal composition is adsorbed, absorbed, or dissolved in a resin carrier, and the resin carrier is subsequently introduced into the polymeric material. ### Claim 13 (depends on 12) The method of claim 12, in which the resin carrier is introduced into the polymeric material composite by co-extruding the resin carrier with the polymeric material. ### Claim 14 A method for making a wood-plastic composite that is resistant to fungal infestation, which method consists of: introducing into the wood-plastic composite an antifungal composition consisting of 3-iodo-2-propynyl-N-n-butylcarbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate in proportions effective for three-component synergy and optionally a solid or liquid vehicle; in which method the proportion of zinc borate is less than 67 mass %, based on the total mass of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate. ### Claim 15 (depends on 14) The method of claim 14, in which 3-iodo-2-propynyl-N-n-butylcarbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate are adsorbed, absorbed, or dissolved in a resin carrier, and the resin carrier is subsequently introduced into the wood-plastic composite. ### Claim 16 (depends on 15) The method of claim 15, in which the wood-plastic composite includes wood and a polymeric material, and the resin carrier is introduced into the wood-plastic composite by co-extruding the resin carrier with the wood, the polymeric material, or a mixture which includes the wood and the polymeric material. ### Claim 17 (depends on 16) The method of claim 16, in which the resin carrier is a composed of a polymer selected from the group consisting of polypropylene polymers, acrylic polymers, vinyl ether polymers, polystyrene-butadiene polymers, polyester polymers, ethylene vinyl alcohol polymers, and mixtures thereof. ### Claim 18 A method for protecting a substrate from fungal infestation, which method consists of treating the substrate with a fungicidally inhibiting amount of an antifungal composition consisting of: 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate, in proportions effective for three-component synergy and optionally a solid or liquid vehicle; in which method the proportion of zinc borate is less than 67 mass %, based on the total mass of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate. ### Claim 19 (depends on 18) The method of claim 18, in which the substrate is a metal working fluid and wherein the antifungal composition is blended with the metal working fluid. ### Claim 20 (depends on 18) The method of claim 18, in which the substrate is a paint and wherein the antifungal composition is blended with the paint. ### Claim 21 A method for making a dry film coating that is resistant to fungal infestation, which method consists of: adding to a film-forming coating precursor an antifungal composition consisting of 3-iodo-2-propynyl-N-n-butylcarbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate in proportions effective for three-component synergy against fungi and optionally a solid or liquid vehicle; and exposing the coating precursor to an oxygen-containing gas to form a dry film coating that is resistant to fungal infestation; in which method the proportion of zinc borate is less than 67 mass %, based on the total mass of 3-iodo-2-propynyl butyl carbamate, 2-(methoxycarbonylamino)benzimidazole, and zinc borate.