# US 8,772,329 B2 · Compounds from mycelium of Antrodia cinnamomea and use thereof

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- Number: US 8,772,329 B2
- Document ID: US8772329B2
- Status: Granted
- Kind: B2
- Application number: 12/811,115
- Filed: 2008-01-28
- Published: 2010-11-11
- Granted: 2014-07-08
- Earliest claimed: 2008-01-28
- Assignees: Simpson Biotech Co., Ltd.
- Applicants: Chia-Chin Sheu; Masao Hattori
- Inventors: Chia-Chin Sheu; Masao Hattori
- Web page: https://patentgrep.com/patent/US8772329B2

## CPC

- C07C 235/34: having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- A61P 31/14: for RNA viruses
- A61P 31/20: for DNA viruses
- C07D 207/444: having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D 207/46: with hetero atoms directly attached to the ring nitrogen atom
- C07D 207/50: Nitrogen atoms
- C07D 307/60: Two oxygen atoms, e.g. succinic anhydride
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) infection.

## Claims

### Claim 1

An isolated compound having the formula III
wherein
R is —(CH2)kCOOH or —(CH2)kCOO(CmH2m+1) wherein k is 0-6 and m is 0-6.

### Claim 2 (depends on 1)

The isolated compound of claim 1, wherein R is —CH2COOH.

### Claim 3

A pharmaceutical composition for inhibiting hepatitis C virus protease, comprising effective amount of an isolated compound having the formula III
wherein
R is —(CH2)kCOOH or —(CH2)kCOO(CmH2m+1) wherein k is 0-6 and m is 0-6,
and a pharmaceutically acceptable carrier.