# US 8,772,328 B2 · Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

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- Number: US 8,772,328 B2
- Document ID: US8772328B2
- Status: Granted
- Kind: B2
- Application number: 14/059,638
- Filed: 2013-10-22
- Published: 2014-02-20
- Granted: 2014-07-08
- Earliest claimed: 2008-11-13
- Assignees: Merck Sharp & Dohme Corp.
- Applicants: Merck Sharp & Dohme Corp.
- Inventors: Tesfaye Biftu; Ann E. Weber
- Web page: https://patentgrep.com/patent/US8772328B2

## CPC

- C07D 309/30: Oxygen atoms, e.g. delta-lactones
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 31/4162: condensed with heterocyclic ring systems
- A61K 38/1709: {from mammals}
- A61K 38/26: Glucagons
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/06: Antihyperlipidemics
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 487/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

## Claims

### Claim 1

A method of treating diabetes in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound which is:
or a pharmaceutically acceptable salt in combination with a sodium-glucose transporter (SGLT) inhibitor.

### Claim 2 (depends on 1)

The method of claim 1, wherein the sodium-glucose transporter (SGLT) inhibitor is a sodium-glucose transporter 2 (SGLT-2) inhibitor.