# US 8,772,324 B2 · Composition and methods for the treatment of wounds

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- Number: US 8,772,324 B2
- Document ID: US8772324B2
- Status: Granted
- Kind: B2
- Application number: 13/260,489
- Filed: 2010-03-18
- Published: 2012-04-19
- Granted: 2014-07-08
- Earliest claimed: 2009-03-25
- Applicants: Keshav Malshe
- Inventors: Keshav Malshe
- Web page: https://patentgrep.com/patent/US8772324B2

## CPC

- A61K 31/4166: having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
- A61K 31/341: not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/415: 1,2-Diazoles
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61L 26/0066: {Medicaments; Biocides}
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61L 2300/204: with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L 2300/428: Vitamins, e.g. tocopherol, riboflavin
- A61L 2300/45: Mixtures of two or more drugs, e.g. synergistic mixtures
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is directed to a wound composition comprising an effective amount of phenytoin and an effective amount of vitamin C. The present invention is further directed to a method of treating a wound in a patient comprising administering an effective amount of phenytoin and an effective amount of vitamin C to the wound.

## Claims

### Claim 1

A method for treating a diabetic ulcer comprising administering to a patient in need thereof a wound composition consisting essentially of an effective amount of phenytoin and an effective amount of vitamin C, wherein the composition is provided in a form comprising a powder, ointment, lotion, cream, and/or gel.

### Claim 2 (depends on 1)

The method of claim 1, wherein the ratio of phenytoin to vitamin C is from about 1:10 to about 1:1.

### Claim 3 (depends on 2)

The method of claim 2, wherein the ratio of phenytoin to vitamin C is about 3:5.

### Claim 4 (depends on 1)

The method of claim 1, wherein the wound composition is administered via topical administration.

### Claim 5 (depends on 1)

The method of claim 1, wherein the wound composition is administered via parenteral administration.

### Claim 6 (depends on 1)

The method of claim 1, wherein the wound composition is administered to the patient at least once daily for at least seven days, and thereafter at least once weekly for at least eight weeks.

### Claim 7

A method for treating a diabetic ulcer comprising administering to a patient in need thereof a pharmaceutical composition consisting essentially of an effective amount of phenytoin, an effective amount of vitamin C, and at least one pharmaceutical acceptable excipient, wherein the pharmaceutical composition is provided in a form comprising a powder, ointment, lotion, cream, and/or gel.