# US 8,772,322 B2 · Synergistic preservative compositions

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- Number: US 8,772,322 B2
- Document ID: US8772322B2
- Status: Granted
- Kind: B2
- Application number: 13/635,118
- Filed: 2011-03-14
- Published: 2013-05-23
- Granted: 2014-07-08
- Earliest claimed: 2010-03-15
- Assignees: ISP Investments Inc.
- Applicants: Gilles Pradier; Alain Girault; Willem Anker; Christophe Amyot
- Inventors: Gilles Pradier; Alain Girault; Willem Anker; Christophe Amyot
- Web page: https://patentgrep.com/patent/US8772322B2

## CPC

- A01N 43/80: five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
- A01N 47/12: containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A preservative composition comprising: (a) 1,2-Benzisothiazolin-3-one (BIT); (b) 3-Iodo-2-propynyl carbamate (IPBC); and (c) a mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-Methyl-4-isothiazolm-3-one (MIT).

## Claims

### Claim 1

A preservative composition comprising:
(a) 1,2-Benzisothiazolin-3-one (BIT);
(b) 3-Iodo-2-propynyl carbamate (IPBC); and
(c) a mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-Methyl-4-isothiazolin-3-one (MIT), wherein the preservative effect of the preservative composition is greater than the sum of the effect of each of BIT, IPBC, CMIT, and MIT alone.

### Claim 2 (depends on 1)

The composition of claim 1 wherein said 1,2-Benzisothiazolin-3-one is present in a total amount of about 1% to 20%.

### Claim 3 (depends on 1)

The composition of claim 1 wherein said 3-Iodo-2-propynyl carbamate is present in a total amount of about 0.5% to 30%.

### Claim 4 (depends on 1)

A composition of claim 1 wherein said mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one and 2-Methyl-4-isothiazolin-3-one is present in a total amount of about 0.01% to 1.5%.

### Claim 5 (depends on 1)

The composition of claim 1 wherein the CMIT and MIT are at a ratio of about 6:4 to 9:1.

### Claim 6 (depends on 1)

The composition of claim 1 comprising about 15% (a), about 2.4% (b) and about 0.4% (c).

### Claim 7 (depends on 6)

The composition of claim 6 wherein (c) comprises a 3:1 ratio of CMIT and MIT.

### Claim 8 (depends on 1)

A method for inhibiting the growth of microorganisms comprising adding a preservative composition in accordance with claim 1 to a product susceptible to growth of microorganisms wherein said composition is added in an amount sufficient to inhibit said growth.