# US 8,772,251 B2 · Use of isothiocyanate derivatives as anti-myeloma agents

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- Number: US 8,772,251 B2
- Document ID: US8772251B2
- Status: Granted
- Kind: B2
- Application number: 12/812,970
- Filed: 2008-12-17
- Published: 2011-03-03
- Granted: 2014-07-08
- Earliest claimed: 2008-01-18
- Assignees: Indena S.p.A.
- Applicants: Paolo Morazzoni; Carla Manzotti; Gabriele Fontana; Antonella Riva; Renato Iori
- Inventors: Paolo Morazzoni; Carla Manzotti; Gabriele Fontana; Antonella Riva; Renato Iori
- Web page: https://patentgrep.com/patent/US8772251B2

## CPC

- A61K 36/31: Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K 31/26: Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
- A61K 31/7024: Esters of saccharides
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention concerns the use of glucomoringin and of its des-thio-glucoside having the following formulae (I, II): for the preparation of a medicament for the treatment of myeloma.

## Claims

### Claim 1

A method for treating multiple myeloma comprising administering an effective amount of a medicament comprising isolated glucomoringin and/or isolated glucomoringin des-thio-glucoside having the following formulas:
to a patient in need thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein said effective amount ranges from between 1 mg/Kg/day to 30 mg/Kg/day.

### Claim 3 (depends on 1)

The method of claim 1, wherein said medicament is isolated glucomoringin.

### Claim 4 (depends on 1)

The method of claim 1, wherein said medicament is isolated glucomoringin des-thio-glucoside.