# US 8,772,243 B2 · Methods for predicting the response to anti-cancer treatment with an agonist of TLR7 or an agonist of TLR8

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- Number: US 8,772,243 B2
- Document ID: US8772243B2
- Status: Granted
- Kind: B2
- Application number: 13/058,113
- Filed: 2009-08-14
- Published: 2011-08-11
- Granted: 2014-07-08
- Earliest claimed: 2008-08-20
- Assignees: Inserm (Institut National De La Sante Et De La Recherche Medicale)
- Applicants: Julien Cherfils; Herve Fridman; Isabelle Cremer
- Inventors: Julien Cherfils; Herve Fridman; Isabelle Cremer
- Web page: https://patentgrep.com/patent/US8772243B2

## CPC

- A61K 31/708: having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
- A61K 31/437: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A61P 35/00: Antineoplastic agents
- C12Q 1/6881: for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- G01N 33/575: for cancer
- G01N 33/5752: of the lungs
- G01N 33/57557: {of other specific parts of the body, e.g. brain}
- G01N 33/5759: {involving compounds localised on the membrane of tumour or cancer cells}
- C12Q 2600/106: Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
- G01N 2333/705: Assays involving receptors, cell surface antigens or cell surface determinants
- G01N 2800/52: Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention relates to methods for predicting the response to treatment with an agonist of TLR7, or an agonist of TLR8 or an anti-cancer agent for treating cancer, in particular non-small cell lung cancer comprising the step of detecting the expression of TLR7 or TLR8 in cancer cells of said patient.

## Claims

### Claim 1

A method for treating a cancer patient who does not express TLR7 in cancer cells comprising
determining whether said cancer patient expresses TLR7 in cancer cells; and
administering a therapeutically effective amount of an agonist of TLR7 if said cancer patient does not express TLR7 in cancer cells.

### Claim 2 (depends on 1)

The method of claim 1 wherein said agonist is used in combination with an anti-cancer agent.

### Claim 3 (depends on 1)

The method of claim 1, wherein said cancer is selected from the group consisting of lung cancer, breast cancer, colorectal cancer, renal carcinoma, prostate cancer, melanoma, and lymphoma.

### Claim 4 (depends on 1)

The method of claim 1, wherein said cancer is a solid cancer.